摘要
糖尿病酮症酸中毒(DKA)是临床上最严重的糖尿病急性并发症,其起病急、病情发展快,严重时可造成昏迷甚至导致死亡。现代药理研究表明,部分中药具有抑制糖原分解、减弱胰岛β细胞损伤、改善胰岛β细胞功能、缓解胰岛素信号传输阻碍等功效,可以有效降低糖尿病小鼠高血糖、高胰岛素血症,也可改善胰岛素抵抗等症状。目前临床上对DKA在胰岛素基础上联合使用清热泻火解毒、益气滋阴养血、凉血活血化瘀、健脾和胃温阳等中药治疗可快速控制病情、缓解症状、降低血糖、促进血酮消失,并纠正酸中毒,同时还可以有效减少胰岛素的用量,从而缩短病程。现从DKA西医发病机制及主要治疗方案、中医病因病机、中医治法和方药文献进行综述,以发挥中医优势,从而为DKA的临床治疗提供参考。
Diabetic ketoacidosis(DKA)is the most serious acute complication of diabetes mellitus,characterized by rapid onset and progression,which can lead to coma or even lead to death in severe cases.Modern pharmacological studies have shown that some traditional Chinese medicines have the efficacy of inhibiting glycogenolysis,attenuating pancreaticβ-cell damage,improving pancreaticβ-cellfunction,and alleviating the obstruction of insulin signalling,which can effectively reduce hyperglycemia and hyperinsulinemia in diabetic mice,as well as improve insulin resistance and other symptoms.At present,the clinical treatment of DKA based on insulin and combined with the use of traditional Chinese medicines,such as clearing heat and diarrhoeing fire to detoxify,benefiting qi and nourishing yin to nourish blood,cooling blood and activate blood circulation to remove blood stasis,strengthening the spleen and the stomach to warm the yang,etc.,can control the condition rapidly.alleviate the symptoms,lower the blood glucose,promote the disappearance of ketones and correct the acidosis,and it can also reduce the dosage of insulin,thus reducing the duration of the disease.This article reviews the literature on the pathogenesis and main treatment options for DKA in western medicine,the etiology and mechanisms of DKA in traditional Chinese medicine,as well as Chinese medicine treatments and prescriptions.The aim is to highlight the advantages of traditional Chinese medicine and provide valuable references for the clinical management of DKA.
作者
刘慧兰
冯燕国
Liu Huilan;Feng Yanguo(Department of Traditional Chinese Medicine and Endocrinology,No.985 Hospital of the Joint Logistics and Security Force of the People's Liberation Army,Taiyuan 030000,Shanxi,China)
出处
《中国中西医结合急救杂志》
CSCD
2024年第5期630-633,共4页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
关键词
中西医结合
糖尿病酮症酸中毒
研究进展
Combined Chinese and western medicine
Diabetic ketoacidosis
Research progress
作者简介
通信作者:冯燕国,Email:8dgoals@sina.com。
