摘要
皮肤病是全球性的公共卫生问题,严重影响着患者的身心健康。中药在皮肤病治疗方面历史悠久,且中药经皮给药相较其它途径,具有避免首过代谢、药物缓释递送等优势,但部分中药活性成分难以高效透皮直达病灶。而纳米载体技术作为一种先进策略,可增强药物透皮性,实现精准靶向递送,提升治疗效果。重点综述了靶向经皮给药策略的纳米制剂设计原则,纳米药物的结构特点以及纳米靶向经皮给药中药制剂在多种皮肤病治疗中的应用。
Skin diseases are a global public health problem,which seriously affect the physical and mental health of patients.Traditional Chinese medicine has a long history in the treatment of skin diseases.Compared with other ways,transdermal administration of traditional Chinese medicine has the advantages of avoiding first-pass metabolism and drug sustained-release delivery,but some active components of traditional Chinese medicine are difficult to penetrate the skin directly to the lesion.As an advanced strategy,nanocarrier technology can enhance the transdermal permeability of drugs,achieve precise targeted delivery,and improve the therapeutic effect.This article focuses on the design principles of nano-preparations for targeted transdermal drug delivery strategies,the structural characteristics of nano-drugs,and the application of nano-targeted transdermal drug delivery traditional Chinese medicine preparations in the treatment of various skin diseases.
作者
王兆宇
杜茂波
谷丽维
刘淑芝
沈硕
WANG Zhaoyu;DU Maobo;GU Liwei;LIU Shuzhi;SHEN Shuo(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Artemisinin Research Center,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《中草药》
CAS
CSCD
北大核心
2024年第21期7557-7566,共10页
Chinese Traditional and Herbal Drugs
基金
中国中医科学院科技创新工程项目(CI2021A04307)
中国中医科学院优秀青年科技人才(创新类)培养专项(ZZ13-YQ-108)
国家中医药管理局项目-中医传统制剂方法(ZZYZK2012)
。
关键词
皮肤病
中药经皮给药
中药活性成分
纳米载体
纳米靶向制剂
skin disease
transdermal administration of traditional Chinese medicine
active ingredients of traditional Chinese medicine
nanocarriers
nano-targeted preparation
作者简介
王兆宇,女,硕士研究生,研究方向为中药新型给药系统。E-mail:wzy740125@163.com;通信作者:沈硕,男,副研究员,硕士生导师,从事中药新型给药系统研究。E-mail:sshen@icmm.ac.cn;通信作者:刘淑芝,女,研究员,博士生导师,从事中药新型给药系统研究。E-mail:liushuhi2004@sina.com。
