摘要
Drug delivery systems(DDS)are defined as methods by which drugs are delivered to desired tissues,organs,cells and subcellular organs for drug release and absorption through a variety of drug carriers.Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility,drug aggregation,low bioavailability,poor biodistribution,lack of selectivity,or to reduce the side effects of therapeutic drugs.During 2015-2018,significant progress in the research on drug delivery systems has been achieved along with advances in related fields,such as pharmaceutical sciences,material sciences and biomedical sciences.This review provides a conciseoverview of current progress in this research area through its focus on the delivery strategies,construction techniques and specific examples.It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues,organs,cells and subcellular organs for drug release and absorption through a variety of drug carriers.Its usual purpose to improve the pharmacological activities of therapeutic drugs and to overcome problems such as limited solubility,drug aggregation,low bioavailability,poor biodistribution,lack of selectivity,or to reduce the side effects of therapeutic drugs.During 2015-2018,significant progress in the research on drug delivery systems has been achieved along with advances in related fields,such as pharmaceutical sciences,material sciences and biomedical sciences.This review provides a conciseoverview of current progress in this research area through its focus on the delivery strategies,construction techniques and specific examples.It is a valuable reference for pharmaceutical scientists who want to learn more about the design of drug delivery systems.
基金
supported by the projects of National Natural Science Foundation of China(Grant Nos.81773650,81690264 and 81673376)
the Drug Innovation Major Project of China(Grant No.2018ZX09721003-004).
作者简介
Chong Li,These authors made equal contributions to this work;Corresponding author:Jiancheng Wang,E-mail address:wang-jc@bjmu.edu.cn,These authors made equal contributions to this work;Yiguang Wang,These authors made equal contributions to this work;Huile Gao,These authors made equal contributions to this work;Gang Wei,These authors made equal contributions to this work;Yongzhuo Huang,These authors made equal contributions to this work;Haijun Yu,These authors made equal contributions to this work;Yong Gan,These authors made equal contributions to this work;Yongjun Wang,These authors made equal contributions to this work;Lin Mei,These authors made equal contributions to this work;Huabing Chen,These authors made equal contributions to this work;Haiyan Hu,These authors made equal contributions to this work;Zhiping Zhang,These authors made equal contributions to this work;Yiguang Jin,These authors made equal contributions to this work
