摘要
纳米技术在改善中药有效成分成药性方面具有广阔的应用前景和巨大潜力。系统阐述了纳米技术的研究进展,探讨了各种纳米技术的相应制备技术、效果和研究方向。综述纳米技术针对性改善中药有效成分口服吸收、改变体内分布、增加靶向性及改善经皮和黏膜吸收方面的方法与优势;分析了纳米技术在改善中药成药性发展中面临的问题,对解决问题的方案提出设想,并对研究方向进行了展望。
Nanotechnology has broad prospects and great potential in improving the druggability of active ingredients of Chinese materia medica（CMM）. This article systematically summarized the methods and advantages of nanotechnology in improving oral absorption, changing the distribution in the body, increasing the targeting ability, and improving transdermal and mucous membrane absorption of active ingredients of CMM. In addition, we analyzed the problems in the development of improving the druggability of active ingredient of CMM by nanotechnology, put forward the strategies for solving these problems, and discussed the research prospects.
作者
高彩芳
夏加璇
朱颖
任宏伟
洪超
陆伟根
王建新
GAO Cai-fang;XIA Jia-xuan;ZHU Ying;REN Hong-wei;HONG Chao;LU Wei-gen;WANG Jian-xin(Key Laboratory of Smart Drug Delivery of Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China;Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, China;Guangzhou University of Chinese Medicine, Guangzhou 510000, China)
出处
《中草药》
CAS
CSCD
北大核心
2018年第12期2754-2762,共9页
Chinese Traditional and Herbal Drugs
关键词
纳米技术
中药有效成分
成药性
口服
靶向
nanotechnology
active ingredients of Chinese materia medica
druggability
oral administration
target
作者简介
高彩芳（1992-），女，硕士研究生，从事新型给药系统研究。Tel：（021）51980086,E-mail：fdgaocaifang@126．com;通信作者 王建新，教授，从事新型给药系统研究。Tel：（021）51980088,E—mail：jxwang@shmu．edu．cn
