摘要
目的:探讨凝血功能指标对社区获得性肺炎患者(Community-acquired pneumonia,CAP)病情程度及预后的评估价值。方法:选取2022年1月至2023年12月收治的CAP患者62例,根据病情严重程度分为低危组和中高危组,根据预后情况分为预后良好组和预后不良组,所有患者均在治疗前检测凝血五项[凝血酶原时间(Prothrombin time,PT)、凝血酶时间(Thrombin time,TT)、活化部分凝血酶原时间(Activated partial thromboplastin time,APTT)、纤维蛋白原(Fibrinogen,FIB)、D二聚体(D-dimer,D-D)],分析CAP患者凝血五项的组间差异,以及凝血五项对CAP病情程度及预后评估的价值。结果:62例CAP患者低危患者33例,中高危患者29例,与低危组比较,中高危组CAP患者PT、TT、APTT、D-D水平升高(P<0.05);62例CAP患者中有53例预后良好,与预后良好组比较,预后不良组CAP患者PT、TT水平升高(P<0.05);ROC曲线分析结果显示,PT、TT、APTT、D-D诊断中高危CAP的AUC范围在0.742~0.927之间(P<0.05),PT、TT评估CAP预后不良的AUC分别为0.840、0.838(P<0.05)。结论:凝血功能指标对CAP病情程度及预后评估具有一定价值,可在临床推广应用。
Objective:To explore value of coagulation function indexes in evaluating disease severity and prognosis of community-acquired pneumonia(CAP).Methods:62 patients with CAP admitted from January 2022 to December 2023 were selected,and divided into low-risk group(n=33)and medium-high-risk group(n=29)according to the disease severity,and classified into good prognosis group and poor prognosis group based on the prognosis status.Five coagulation indexes[prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(FIB),D-dimer(D-D)]were detected before treatment.The differences in five coagulation indexes in CAP patients and value on disease severity and prognosis evaluation of CAP were analyzed.Results:There were 33 low-risk patients and 29 medium-high-risk patients among 62 CAP patients.Compared with low-risk group,the PT,TT,APTT and D-D of CAP patients in medium-high-risk group were significantly increased(P<0.05).53 cases had a good prognosis among 62 CAP patients.Compared with good prognosis group,the PT and TT of CAP patients in poor prognosis group were enhanced(P<0.05).ROC curve analysis showed that the AUCs of PT,TT,APTT and D-D in the diagnosis of medium-high-risk CAP ranged from 0.742 to 0.927(P<0.05).The AUCs of PT and TT in the evaluation of poor prognosis of CAP were 0.840,0.838 respectively(P<0.05).Conclusion:Coagulation function indexes have some value on disease severity and prognosis evaluation of CAP,and can be widely used in clinical practice.
作者
李早生
肖美秀
郭华拯
Li Zao-sheng;Xiao Mei-xiu;Guo Hua-zheng(Department of Clinical Laboratory,Yongfeng Maternal and Child Health Hospital,Ji'an 331500,Jiangxi,China;Nursing Department,Tan Urban and Rural Health Center of,Yongfeng,Ji'an 331500,Jiangxi,China)
关键词
社区获得性肺炎
凝血功能指标
病情程度
预后
Community-acquired pneumonia
Coagulation function index
Disease severity
Prognosis
作者简介
李早生,男,主管技师,主要从事于检验科工作,Email:13479077774@163.com。
