摘要
目的探讨抑癌蛋白M(oncostatin M,OSM)在脓毒症患者中的表达及其对脓毒症早期识别的价值。方法选取山西白求恩医院2021年6月3日至2022年1月18日期间收治的脓毒症患者34例作为脓毒症组,社区获得性肺炎(community acquired pneumonia,CAP)患者15例作为病例对照组,并选取同期在本院进行健康体检的成人16位作为健康对照组。追踪随访脓毒症组患者28天转归情况,分为存活组和死亡组。分析各组受试者血清OSM水平及其与临床指标(白细胞、中性粒细胞、淋巴细胞计数、序贯器官衰竭评分及急性生理学和慢性健康状况评价Ⅱ)评分的关联性,并分析OSM表达水平对脓毒症早期识别的诊断价值。结果与病例对照组和健康对照组相比,脓毒症组患者OSM表达水平明显增高[(502.07±209.93)pg/mL比(368.22±65.95)pg/mL和(382.09±73.04)pg/mL,P<0.05]。OSM高表达与白细胞、中性粒细胞、淋巴细胞计数及疾病严重度评分均无明显相关性(P>0.05),脓毒症存活组患者与死亡组患者血清OSM水平差异无统计学意义。相较于白细胞计数,OSM高表达在脓毒症早期识别中有一定的诊断价值,OSM预测脓毒症发生的受试者操作特征曲线下面积为0.794(95%可信区间0.666~0.922,P<0.05),敏感性为79.4%,特异性为73.3%。结论脓毒症患者OSM表达明显增高,而且相较于白细胞计数,OSM高表达在脓毒症早期识别中有一定的诊断价值。
Objective To investigate the expression of oncostatin M(OSM)in patients with sepsis and its role in early recognition of sepsis.Methods Thirty-four patients with sepsis admitted in Shanxi Bethune Hospital from June 3,2021 to January 18,2022 were selected as a sepsis group,15 patients with community acquired pneumonia(CAP)as a case control group,and 16 adults who underwent physical examination in the same period were selected as a healthy control group.The patients in the sepsis group were followed up for 28 days and divided into a survival group and a death group.The serum OSM level and its correlation with clinical indexes(white blood cell,neutrophil,lymphocyte,sequential organ failure assessment score and acute physiology and chronic health evaluationⅡ)were analyzed,and the diagnostic value of OSM expression level in the early identification of sepsis was analyzed.Results Compared with the case control group and the healthy control group,the expression level of OSM in the sepsis group was significantly higher[(502.07±209.93)pg/mL vs.(368.22±65.95)pg/mL and(382.09±73.04)pg/mL,P<0.05].However,the high expression of OSM had no significant correlation with white blood cell,neutrophil,lymphocyte or disease severity score(P>0.05),and there was no significant difference in serum OSM level between the sepsis survival group and the death group.Compared with white blood cell count,the high expression of OSM has certain diagnostic value in the early identification of sepsis.The area under the receiver operator characteristic curve of OSM in predicting sepsis was0.794(95%confidence interval 0.666-0.922,P<0.05),with the sensitivity of 79.4%and the specificity of 73.3%.Conclusion The expression of OSM in patients with sepsis is significantly increased,and the high expression of OSM has a certain diagnostic value in the early identification of sepsis.
作者
樊柳汝
张丽中
李金兰
李筱妍
FAN Liuru;ZHANG Lizhong;LI Jinlan;LI Xiaoyan(Department of Respiratory and Critical Care Medicine,Third Hostipal of Shanxi Medical University,Shanxi Bethune Hostipal,Tongji Shanxi Hospital,Taiyuan,Shanxi 030032,P.R.China;Clinical Laboratory,Third Hostipal of Shanxi Medical University,Shanxi Bethune Hostipal,Tongji Shanxi Hospital,Taiyuan,Shanxi 030032,P.R.China)
出处
《中国呼吸与危重监护杂志》
CAS
CSCD
北大核心
2022年第6期412-416,共5页
Chinese Journal of Respiratory and Critical Care Medicine
基金
山西省留学人员科技活动择优资助项目(20200030)
作者简介
通信作者:李筱妍,Email:2415960869@qq.com
