摘要
目的观察奥美拉唑联合双歧杆菌三联活菌片治疗功能性消化不良的疗效,并探讨其对患儿血清神经肽Y(NPY)水平及摄食情况的影响。方法选择2021年1月至2024年1月中山市博爱医院收治的80例功能性消化不良患儿作为研究对象,按随机数表法分为观察组和对照组各40例。对照组患儿采用双歧杆菌三联活菌片治疗,观察组患儿在对照组治疗的基础上联合奥美拉唑肠溶胶囊治疗,两组患儿均持续治疗4周。比较两组患儿治疗4周后的临床疗效、症状(早饱感、餐后饱胀感、上腹部疼痛、上腹部灼烧感)缓解时间,并比较两组患儿治疗前后的血清NPY、膳食多样化评分(DDS)和治疗期间的不良反应发生率。结果治疗后,观察组患儿的临床总有效率为92.50%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);观察组患儿的早饱感、餐后饱胀感、上腹部疼痛及灼烧感的缓解时间分别为(12.83±2.17)d、(13.55±2.61)d、(3.35±0.63)d、(3.20±0.61)d,明显短于对照组的(15.20±2.79)d、(16.47±2.84)d、(3.91±0.65)d、(3.82±0.68)d,差异均有统计学意义(P<0.05);治疗后,观察组患儿的血清NPY水平为(45.02±4.62)ng/L,明显高于对照组的(37.45±4.25)ng/L,DDS评分为(16.20±1.22)分,明显高于对照组的(13.83±1.37)分,差异均有统计学意义(P<0.05);观察组患儿的不良反应发生率为5.00%,略高于对照组的2.50%,但差异无统计学意义(P>0.05)。结论奥美拉唑联合双歧杆菌三联活菌片治疗功能性消化不良患儿的效果明显,可有效调节患儿血清NPY水平,改善摄食情况,具有临床应用价值。
Objective To observe the efficacy of omeprazole combined with Bifidobacterium triple viable tablets in the treatment of functional dyspepsia,and to explore its effect on the level of serum neuropeptide Y(NPY)and feeding status of children.Methods Eighty children with functional dyspepsia admitted to Bo'ai Hospital of Zhongshan from January 2021 to January 2024 were selected and divided into an observation group and a control group according to random number table method,with 40 patients in each group.The children in the control group were treated with Bifidobacterium triple viable tablets,and those in the observation group were treated with omeprazole enteric-coated capsule on the basis of the treatment in the control group,all for 4 weeks.The clinical efficacy and relief time of symptoms(early satiety,postprandial fullness,upper abdominal pain,upper abdominal burning)after 4 weeks of treatment were compared between the two groups.The serum NPY,Dietary Diversity Score(DDS)before and after treatment,and the incidence of adverse reactions during treatment were compared between the two groups.Results After treatment,the total clinical effective rate in the observation group was 92.50%,which was significantly higher than 75.00%in the control group(P<0.05).The relief time of early satiety,postprandial fullness,upper abdominal pain,and upper abdominal burning in the observation group were(12.83±2.17)d,(13.55±2.61)d,(3.35±0.63)d,and(3.20±0.61)d,which were significantly shorter than(15.20±2.79)d,(16.47±2.84)d,(3.91±0.65)d,and(3.82±0.68)d in the control group(P<0.05).After treatment,the serum NPY level in the observation group was(45.02±4.62)ng/L,which was significantly higher than(37.45±4.25)ng/L in the control group;the DDS score in the observation group was(16.20±1.22)points,significantly higher than(13.83±1.37)points in the control group;the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%,which was slightly higher than 2.50%in the control group(P>0.05).Conclusion Omeprazole combined with Bifidobacterium triple viable tablets has significant effect in the treatment of children with functional dyspepsia,which can effectively regulate the level of serum NPY and improve the feeding status of children.
作者
张丽
谢春华
杨惠芳
梁晓婷
林凯丽
梁展图
ZHANG Li;XIE Chun-hua;YANG Hui-fang;LIANG Xiao-ting;LIN Kai-li;LIANG Zhan-tu(Children's Digestive Department,Bo'ai Hospital of Zhongshan,Zhongshan 528400,Guangdong,CHINA;Department of Pediatrics,Bo'ai Hospital of Zhongshan,Zhongshan 528400,Guangdong,CHINA)
出处
《海南医学》
CAS
2024年第21期3104-3107,共4页
Hainan Medical Journal
基金
广东省中山市第一批社会公益与基础研究项目(编号:2021B1077)。
关键词
儿童
功能性消化不良
双歧杆菌三联活菌片
奥美拉唑
神经肽Y
摄食情况
Children
Functional dyspepsia
Bifidobacterium triple active powder
Omeprazole
Neuropeptide Y
Feeding condition
作者简介
第一作者:张丽(1987-),女,主治医师,主要研究方向为儿童消化道疾病诊治;通讯作者:梁展图(1980-),男,主任医师,主要研究方向为儿童消化道疾病诊治,E-mail:313068103@qq.com。
