摘要
单糖在肿瘤细胞的能量代谢和生物合成中起重要作用。与正常细胞相比,肿瘤细胞及其所处微环境存在很大的代谢异质性。因此,单糖代谢是肿瘤研究的焦点之一。甘露糖是一种广泛分布于人体的单糖,具有多重生理功效。最近研究证明,甘露糖对多种恶性肿瘤具有抑制作用,其机制包括:影响葡萄糖代谢,调控靶基因与信号通路,调节免疫功能、氧化应激及体内微生物组等。体内外实验结果表明,甘露糖还可增强化疗、放疗、免疫治疗、靶向治疗的疗效,具有作为抗肿瘤药物的潜能。本文就近年来甘露糖在体内外的直接抗肿瘤作用研究作一综述,分析其作用机制与应用前景,以期为后续研究及临床应用提供理论支持。
Monosaccharides play an important role in energy metabolism and biosynthesis of tumor cells.Compared with normal cells,tumor cells and their microenvironment have great metabolic heterogeneity.Therefore,the monosaccharide metabolism is one of the focuses of tumor research.Mannose is a kind of monosaccharide widely distributed in the human body,with multiple physiological effects.Recent studies have shown that mannose has inhibitory effects on various malignant tumors,and its mechanisms include interfering with glucose metabolism,regulating target genes and signaling pathways,modulating immune function,oxidative stress and the microbiome in vivo,etc.The results of in vitro and in vivo experiments have shown that mannose can also enhance the efficacy of chemotherapy,radiotherapy,immunotherapy,targeted therapy,and has the potential as an adjuvant drug for anti-tumor.The mechanisms and application prospects of mannose are discussed in this paper,in order to provide theoretical support for follow-up researches and clinical application.
作者
吴品庚
刘溪
曾宇
WU Pingeng;LIU Xi;ZENG Yu(Department of Urology,the Cancer Hospital of Dalian University of Technology/Liaoning Cancer Hospital,Shenyang 110042,China)
出处
《生命的化学》
CAS
2024年第8期1368-1375,共8页
Chemistry of Life
基金
辽宁省科学技术计划项目(2023JH2/101300060)。
关键词
甘露糖
糖代谢
肿瘤代谢
抗肿瘤治疗
mannose
glucose metabolism
tumor metabolism
anti-tumor therapy
作者简介
第一作者:吴品庚,E-mail:wupingeng@foxmail.com;通信作者:曾宇,E-mail:zengyudo7@foxmail.com。
