摘要
脓毒症(sepsis)是一种由严重感染引起的宿主失控的炎症反应,从而导致多器官功能障碍的一组综合征。细胞焦亡是一种程序性细胞死亡方式,在脓毒症级联放大的炎症反应中发挥重要作用。Gasdermin蛋白是近年来发现的可被经典焦亡途径和非经典焦亡激活并发生剪切,从而在细胞质膜上打孔,最终造成了细胞的炎性程序性死亡的关键蛋白,是细胞焦亡的执行者。深化对Gasdermin蛋白的认识、理解Gasdermin蛋白在脓毒症失控炎症反应中的作用,将有助于进一步了解焦亡相关的失控炎症反应在脓毒症发生发展中的作用及Gasdermin蛋白在脓毒症病理生理机制中的作用,并为后续脓毒症的炎症反应调控及治疗提供新的思路。本文对Gasdermin蛋白家族在脓毒症细胞焦亡中的作用和机制作一综述,并对其作为炎症免疫调控治疗的靶点进行展望。
Sepsis is a syndrome characterized by uncontrolled host inflammation triggered by severe infection,often leads to multi-organ dysfunction.Pyroptosis is a programmed cell death mechanism that significantly amplifies the inflammatory cascade during sepsis.Gasdermin proteins,discovered recently,play pivotal roles in executing this inflammatory cell death process by creating pores in the cytoplasmic membrane upon cleavage,activated through both canonical and non-canonical pyroptosis pathways.Enhancing our comprehension of Gasdermin proteins is crucial to grasp their contribution to the uncontrolled inflammatory response in sepsis.Such an understanding is vital to unravel the connection between pyroptosis-driven inflammation and the onset and progression of sepsis.Additionally,it would elucidate the role of Gasdermin proteins in the pathophysiological mechanism of sepsis,thereby providing new insights for the subsequent regulation and treatment of the inflammatory response in sepsis.We reviewed the Gasdermin protein family's role and mechanisms in pyroptosis in sepsis.It also highlights the potential for Gasdermins as targets for immune modulation in combating inflammation in sepsis.
作者
孙骎
杨毅
彭菲
Sun Qin;Yang Yi;Peng Fei(Jiangsu Provincial Key Laboratory of Critical Care Medicine,Department of Critical Care Medicine,Zhongda Hospital,School of Medicine,Southeast University,Nanjing 210009,China)
出处
《中华重症医学电子杂志》
CSCD
2023年第4期379-384,共6页
Chinese Journal Of Critical Care & Intensive Care Medicine(Electronic Edition)
基金
国家自然科学基金项目(81901945,81971888,82202393)
国家重点研发计划项目(2022YFC2504400)
江苏省重点研发计划项目(BE2022854)
作者简介
通信作者:彭菲,Email:afei0312@163.com
