摘要
目的观察“从气守神”推拿法对广泛性焦虑症(generalized anxiety disorder,GAD)的治疗效果及对血清5-羟色胺(5-hydroxytryptamine,5-HT)、P物质(substance P,SP)水平的影响。方法将58例GAD患者随机分为试验组和对照组,每组29例;试验组采用“从气守神”推拿法治疗,对照组采用常规推拿法治疗。比较两组患者治疗前后汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)、焦虑自评量表(self-rating anxiety scale,SAS)、肝气郁结型中医证候量表、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)量表评分,血清5-HT、SP水平。结果试验组临床疗效优于对照组(P<0.05)。治疗后两组患者HAMA、SAS、肝气郁结证中医证候量表及PSQI量表评分均较治疗前显著减少(P<0.05);试验组HAMA、SAS及PSQI量表评分较对照组显著减少(P<0.05)。与治疗前比较,两组患者治疗后血清5-HT水平均显著升高(P<0.05),SP水平均显著降低(P<0.05),试验组升高和降低程度较对照组更显著(P<0.05)。结论“从气守神”推拿法可调节GAD患者血清5-HT、SP水平,调节脑—肠轴,从而有效改善患者情绪焦虑、失眠等临床症状。
Objective To investigate the clinical effect of Qi-following and spirit-maintaining massage in the treatment of generalized anxiety disorder(GAD)and its influence on the serum levels of 5-hydroxytryptamine(5-HT)and substance P(SP).Methods A total of 58 patients with GAD were randomly divided into experimental group and control group,with 29 patients in each group.The patients in the experimental group received Qi-following and spirit-maintaining massage,and those in the control group received conventional massage.The two groups were compared in terms of Hamilton Anxiety Scale(HAMA),self-rating anxiety scale(SAS),TCM syndrome scale of stagnation of liver Qi,Pittsburgh Sleep Quality Index(PSQI)score,and the serum levels of 5-HT and SP before and after treatment.Results The experimental group had a significant better clinical outcome than the control group(P<0.05).After treatment,both groups had significant reductions in the scores of HAMA,SAS,TCM syndrome scale of stagnation of liver Qi,and PSQI(P<0.05),and compared with the control group,the experimental group had significantly lower HAMA,SAS,and PSQI scores(P<0.05).After treatment,both groups had a significant increase in the serum level of 5-HT and a significant reduction in the serum level of SP(P<0.05),and the experimental group had significantly greater changes than the control group(P<0.05).Conclusion For patients with GAD,Qi-following and spirit-maintaining massage can regulate the serum levels of 5-HT and SP and the brain-gut axis,thereby effectively improving the clinical symptoms of anxious emotion and sleep.
作者
张静
李伟彪
王雪霞
董升
桑亚男
詹巍
郭现辉
ZHANG Jing;LI Weibiao;WANG Xuexia;DONG Sheng;SANG Yanan;ZHAN Wei;GUO Xianhui(Henan University of Chinese Medicine,Henan Zhengzhou 450000,China;The Third Affiliated Hospital of Henan University of Chinese Medicine,Henan Zhengzhou 450000,China)
出处
《安徽中医药大学学报》
CAS
2024年第4期60-65,共6页
Journal of Anhui University of Chinese Medicine
基金
河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-09)。
关键词
广泛性焦虑症
“从气守神”推拿法
5-羟色胺
P物质
Generalized anxiety disorder
Qi-following and spirit-maintaining massage
5-Hydroxytryptamine
Substance P
作者简介
张静(1997-),女,硕士研究生;通信作者:郭现辉(1973-),女,博士,主任医师,硕士研究生导师,gxhhactcm@126.com。
