摘要
动物实验是中医药科学研究的关键环节,证候动物模型是中医药类动物实验的重要研究对象,良好的再现性、可重复性、专一性、安全性、便捷性、经济性是动物模型的基本要求。近年来,随着肺脏病动物实验研究的不断开展,相关证候动物模型构建和评价方法得到一定完善,但在模型评价方面仍存在主观描述多、精确量化少,宏观表征多、微观证据少,病相关指标多、证相关指标少,指标缺乏主次分层等问题。因此,笔者基于文献综述方法系统梳理了目前肺脏病证候模型的研究进展,并提出加强模型动物四诊表现及反应特征规律研究、造模干预措施标准化研究、四诊信息采集工具和客观化评价研究、中医证候模型评价量表研究可能作为未来模型优化的可行途径。以期通过本文对未来肺脏病证候模型的研究提供新的思路和方法。
Animal experiment is a key link in the scientific research of traditional Chinese medicine,and the syndrome animal model is an important research object in the animal experiment of traditional Chinese medicine.Good reproducibility,repeatability,specificity,safety,convenience and economy are the basic requirements of animal model.In recent years,with the continuous development of animal experimental studies on lung diseases,the animal model construction and evaluation methods of related syndromes have been improved to a certain extent.However,in terms of model evaluation,problems such as more subjective descriptions,less accurate quantification,more macro representations,less microscopic evidence,more disease-related indicators,less syndrome-related indicators,and lack of primary and secondary stratification of indicators continue to be prominent.Therefore,based on the literature review method,the author systematically reviewed the current research progress of lung disease syndrome models,and proposed that strengthening the research on the four-diagnosis manifestations and reaction characteristics of model animals,standardization of modeling interventions,four-diagnosis information collection tool and the objective evaluation study,and the TCM syndrome model evaluation scale study might be feasible approaches for future model optimization.In order to provide new ideas and methods for the study of the syndrome model of lung disease in the future.
作者
臧凝子
李品
庞立健
吕晓东
战丽彬
ZANG Ningzi;LI Pin;PANG Lijian;LYU Xiaodong;ZHAN Libin(School of Chinese Medicine of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China;Office of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2024年第3期721-730,共10页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
中国博士后科学基金面上项目(2022MD723797)
基于HIF-1α/BNIP3L信号补肺健脾通络法抑制线粒体自噬改善COPD合并骨骼肌功能障碍机制研究,负责人:臧凝子
国家自然科学基金委员会面上项目(82274440)
益气养阴活血通络法调控周细胞-内皮细胞Ang/Tie2信号恢复内皮生态位改善血管通透性治疗IPF机制研究,负责人:吕晓东
中央引导地方科技发展资金(自由探索类基础研究)(2023JH6/100100025)
基于TGF-β1/Smads信号通路泛素化修饰探讨益气养阴活血通络法“去菀陈莝”抑制EMT改善IPF的疗效机制研究,负责人:吕晓东。
关键词
肺脏病
证候模型
研究进展
指标体系
量表
Lung disease
Syndrome model
Research progress
Indicator system
Scale
作者简介
通讯作者:战丽彬,本刊编委,教授,博士研究生导师,博士,主要研究方向:基本证候辨证标准系统研究。
