摘要
目的:探讨血清微小RNA-150-5p(miR-150-5p)、微小RNA-196a(miR-196a)、微小RNA-21-5p(miR-21-5p)水平与宫颈癌患者病理参数的相关性。方法:选取2020年1月至2023年1月该院收治的130例宫颈癌患者设为宫颈癌组,82例癌前病变患者设为癌前病变组,同期130名健康体检者设为对照组。比较三组血清miR-150-5p、miR-196a、miR-21-5p水平,并分析其与宫颈癌患者病理参数的相关性。结果:宫颈癌组、癌前病变组血清miR-150-5p、miR-196a、miR-21-5p水平均高于对照组,且宫颈癌组高于癌前病变组,差异有统计学意义(P<0.05);不同年龄、肿瘤直径、病理类型宫颈癌患者血清miR-150-5p、miR-196a、miR-21-5p水平比较,差异均无统计学意义(P>0.05);低分化、国际妇产科联盟(FIGO)分期Ⅲ~Ⅳ期、有淋巴结转移、浸润深度>1/2宫颈癌患者血清miR-150-5p、miR-196a、miR-21-5p水平均高于中高分化、FIGO分期Ⅰ~Ⅱ期、无淋巴结转移、浸润深度≤1/2宫颈癌患者,差异有统计学意义(P<0.05);Pearson相关性分析结果显示,血清miR-150-5p、miR-196a、miR-21-5p水平与宫颈癌患者FIGO分期、淋巴结转移、浸润深度均呈正相关(r>0,P<0.05),与分化程度呈负相关(r<0,P<0.05)。结论:血清miR-150-5p、miR-196a、miR-21-5p水平与宫颈癌患者FIGO分期、淋巴结转移、浸润深度均呈正相关,与分化程度呈负相关。
Objective:To investigate correlations among serum microRNA-150-5p(miR-150-5p),microRNA-196a(miR-196a),microRNA-21-5p(miR-21-5p)levels and pathological parameters of cervical cancer patients.Methods:130 patients with cervical cancer admitted to this hospital from January 2020 to January 2023 were selected as the cervical cancer group,82 patients with precancerous lesions were set as the precancerous lesion group,and 130 healthy subjects were set as the control group.The levels of serum miR-150-5p,miR-196a and miR-21-5p were compared among the three groups.The correlations among them and the pathological parameters of these cervical cancer patients were analyzed.Results:The levels of serum miR-150-5p,miR-196a and miR-21-5p in the cervical cancer group and the precancerous lesion group were higher than those in the control group,those in the cervical cancer group were higher than those in the precancerous lesion group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the serum levels of miR-150-5p,miR-196a,and miR-21-5p among the cervical cancer patients of different ages,tumor diameters,and pathological types(P>0.05).The levels of serum miR-150-5p,miR-196a and miR-21-5p in the cervical cancer patients with low differentiation,federation international of gynecology and obstetric(FIGO)stage III-IV,lymph node metastasis and infiltration depth>1/2 were higher than those in the patients with high differentiation,FIGO stage I-II,no lymph node metastasis and infiltration depth≤1/2 cervical cancer,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum levels of miR-150-5p,miR-196a and miR-21-5p were positively correlated with FIGO stage,lymph node metastasis and invasion depth in the patients with cervical cancer(r>0,P<0.05),and negatively correlated with the differentiation degree(r<0,P<0.05).Conclusions:The serum miR-150-5p,miR-196a and miR-21-5p levels are positively correlated with FIGO stage,lymph node metastasis and invasion depth in the patients with cervical cancer,and negatively correlated with the differentiation degree.
作者
段情
房爱芳
黄相艳
李秀芳
DUAN Qing;FANG Aifang;HUANG Xiangyan;LI Xiufang(2^(nd)Department of Gynecology of Anyang Tumor Hospital,Anyang 455000 Henan,China)
出处
《中国民康医学》
2024年第12期130-133,共4页
Medical Journal of Chinese People’s Health
作者简介
段情(1989.10-),女,汉族,河南睢县人,硕士研究生,主治医师,研究方向为宫颈癌、子宫内膜癌、卵巢癌等。
