摘要
“脑-心-肾-精室”轴理论是基于中医基础理论、现代男科疾病发病特点,结合临床实践提出的中医男科理论。以该轴为切入点,认为脑、心和肾脏腑失调及精室失用为早泄的核心病机,精室失用导致精窍开阖失控是发病的最终环节。从“脑-心-肾-精室”轴理论辨治早泄,更清晰地把握早泄中医发病观,治疗上突出对涉病脏腑的整体调控,同时注重心身同治。通过探讨“脑-心-肾-精室”轴与早泄的生物学基础,提出早泄与“脑-心-肾-精室”轴之间的生物学基础主要与局部脑区功能下降、神经调节失常、中枢神经递质失调、内分泌紊乱及阴茎感觉传入增强等有关,旨在为中医药防治早泄提供新的研究路径,并为开发更有效的治疗方法提供科学依据。
The theory of"brain-heart-kidney-semen chamber"axis is proposed based on the basic theories of traditional Chinese medicine,the modern physiological characteristics of men's diseases,and clinical practice.According to this theory,dysfunctions of the brain,heart,kidney,and semen chamber are the core mechanisms for the occurrence of premature ejaculation,and the loss of control of the opening and closing of the seminal orifices due to the dysfunction of the semen chamber is the final link in the occurrence of premature ejaculation.The treatment of premature ejaculation based on the theory of"brain-heart-kidney-essence chamber"axis highlights the overall regulation of the Zang-fu organs involved in the disease,while focusing on the simultaneous treatment of the mind and body.By exploring the biological basis of the"brain-heart-kidneyessence chamber"axis and premature ejaculation,we propose that the biological basis of premature ejaculation and the axis is mainly related to the function decline of the local brain area,neuromodulation malfunction,central neurotransmitter imbalance,endocrine disorders,and enhanced sensory afferents of the penis.This study aims at providing a new approach for the prevention and treatment of premature ejaculation by traditional Chinese medicine and a scientific basis for the development of more effective therapeutic methods.
作者
马东岳
王安民
杨九天
骆第铖
赵子维
郭军
王福
MA Dongyue;WANG Anmin;YANG Jiutian;LUO Dicheng;ZHAO Ziwei;GUO Jun;WANG Fu(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第10期203-209,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局高水平中医药重点学科建设项目(zyyzdxk-2023238)
国家自然科学基金面上项目(81873182)
中国中医科学院科技创新工程项目(CI2021A02203)
中国中医科学院“优势病种-医院制剂-新药”研发专项(ZZ15-XY-PT-06)。
关键词
早泄
“脑-心-肾-精室”轴
5-羟色胺
神经递质
生物学基础
premature ejaculation
"brain-heart-kidney-semen chamber"axis
5-hydroxytryptamine
neurotransmitters
biological basis
作者简介
第一作者:马东岳,硕士,从事中西医结合治疗男科病研究,E-mail:raymur@163.com;通信作者:王福,副主任医师,硕士生导师,从事中西医结合治疗男科病研究,E-mail:fu311306@163.com。
