摘要
目的:探讨达泊西汀联合经皮神经肌肉电刺激(TNES)治疗原发性早泄的临床疗效。方法:选取60例符合原发性早泄诊断标准的患者作为研究对象,随机分为达泊西汀组(对照组)、达泊西汀联合经皮神经肌肉电刺激组(观察组)。每组30例,治疗4周;记录两组治疗前后的阴道内射精潜伏时间(IELT)、早泄诊断量表(PEDT)评分、阴茎交感神经皮肤反应(PSSR)以及抑郁症筛查量表(PHQ-9)评分和焦虑症筛查量表(GAD-7)评分的相关数据。分析治疗前后组内和组间观察指标变化差异以及两组有效率比较。结果:观察组和对照组的IELT和PSSR潜伏期均延长、PEDT评分均下降,差异具有统计学意义(P<0.01)。观察组与对照组相比,在延长IELT和PSSR潜伏期、降低PEDT评分方面,差异具有统计学意义(P<0.05)。观察组与对照组有效率分别为90%、63.33%,差异有统计学意义(P<0.05);两组在改善抑郁焦虑水平方面无明显差异(P>0.05)。结论:达泊西汀联合TNES比单用达泊西汀药物治疗原发性早泄的临床效果更佳,可以作为临床治疗原发性早泄的一种可供选择的有效方案。
Objective:To investigate the clinical efficacy of dapoxetine combined with transcutaneous neuromuscular electrical stimulation(TNES)in the treatment of primary premature ejaculation.Methods:A total of 60 patients who met the diagnostic criteria for primary premature ejaculation were selected as study subjects and randomly divided into a dapoxetine group(control group)and a dapoxetine combined with percutaneous neuromuscular electrical stimulation group(observation group).30 patients in each group were treated for 4 weeks.Intravaginal ejaculatory latency time(IELT),the score of Premature Ejaculation Diagnostic Tool(PEDT),sympathetic skin response located in the penis(PSSR),Patient Health Questionnaire(PHQ-9),and Generalized Anxiety Disorder Questionnaire(GAD-7)before and after treatment were recorded in the two groups.Before and after treatment,the difference in observed indexes in the two groups and the comparison of effective rates between the two groups were analyzed.Results:The latency of IELT and PSSR was prolonged and the PEDT score was decreased in both the observation group and the control group,the difference was statistically significant(P<0.01).Compared with the control group,the observation group had statistically significant differences in extending IELT and PSSR latency and reducing PEDT score(P<0.05).The effective rates of the observation group and control group were 90%and 63.33%,respectively,and the difference was statistically significant(P<0.05).There was no significant difference in the improvement of depression and anxiety levels between the two groups(P>0.05).Conclusion:Dapoxetine combined with TNES has a better clinical effect than dapoxetine alone in the treatment of primary premature ejaculation,and can be used as an effective option for clinical treatment of primary premature ejaculation.
作者
徐兵
贡永战
刘凯峰
张胜民
张绍
朱攀焱
王子豪
芦鹏杰
谢子松
XU Bing;GONG Yong-zhan;LIU Kai-feng;ZHANG Sheng-min;ZHANG Shao;ZHU Pan-yan;WANG Zi-hao;LU Peng-jie;XIE Zi-song(The first affiliated,hospital of Nanyang medical college,Nanyang,Henan 473000,China;Dalian Medical University,Dalian,Liaoning 116044,China;The Yangzhou School of Clinical Medicine of Dalian Medical University,Dalian,Liaoning 225001,China; Yangzhou University,Yangzhou,Jiangsu 225001,China;Yangzhou Clinical College of Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;Northern Jiangsu Peoples Hos-pital/Northern Jiangsu People's Hospital of Jiangsu Province,Yangzhou,Jiangsu 225001,China;Xiangyang Hospital of Traditional Chinese Medicine,Xiangyang,Hubei 441000,China;Qichun Peoples Hospital,Qichun,Hubei 435300,China)
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2023年第9期815-820,共6页
National Journal of Andrology
基金
国家卫生健康委医药卫生科技发展研究中心课题项目(HDSL202001051)
江苏省苏北人民医院第七批院级扶持技术项目(FCJS202354)
江苏省苏北人民医院2021年度交叉合作项目(SBJC21018)
关键词
达泊西汀
经皮神经肌肉电刺激
原发性早泄
dapoxetine
percutaneous neuromuscular electrical stimulation
primary premature ejaculation
作者简介
共同第一作者:徐兵(1997-),男,湖北荆州市人,医师,硕士研究生,从事男科学和泌尿外科学专业。Email:354582405@qq.com。对本研究有同等贡献;共同第一作者:贡永战(1997-),男,江苏扬州市人,医师,硕士研究生,从事男科学和泌尿外科学专业。Email:986570550@qq.com。对本研究有同等贡献;通讯作者:刘凯峰,Email:18051062336@yzu.edu.cn
