摘要
目的 探究使用血栓通联合天麻素对后循环缺血性眩晕症(PCIV)患者血管内皮功能、炎症因子的影响。方法 纳入2020年12月至2022年11月在启东市人民医院就诊的PCIV患者为研究对象,随机分为试验组和对照组。对照组给予血栓通300 mg,ivgtt,试验组在给予血栓通的基础上联合天麻素0.6 g,ivgtt,两组均治疗15d。采用用美国加州大学洛杉矶分校眩晕患者问卷自评表(UCLA-DQ)、视觉性眩晕量表(VVAS)评估两组患者干预前后的眩晕症状治疗情况。检测两组血清同型半胱氨酸(Hcy)、内皮素-1(ET-1)、一氧化氮(NO)水平评估血管内皮功能;检测血清高敏C-反应蛋白(hs-CRP)、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)浓度评估炎症水平。采用彩色多普勒超声系统记录基底动脉、左椎动脉及右椎动脉平均血液流速。结果 研究共纳入PCIV患者96例,每组各48例。治疗后,试验组UCLADQ、VVAS量表评分均低于对照组(P <0.05);试验组血Hcy、ET-1、hs-CRP、TNF-α、IL-6水平低于对照组,但NO水平高于对照组(P <0.05);试验组基底动脉、左椎动脉及右椎动脉平均血液流速均高于对照组(P <0.05)。结论 血栓通联合天麻素较单用血栓通能显著改善PCIV患者的眩晕症状,还能保护血管内皮功能,抑制炎症因子,促进脑血流动力学指标改善。
Objective To explore the effects of Xueshuantong combined with gastrodin on vascular endothelial function and inflammatory factors in patients with posterior circulation ischemic vertigo(PCIV).Methods Patients with PCIV who were admitted to Qidong People's Hospital from December 2020 to November 2022 were randomly divided into experimental group and control group.The control group was given 300 mg intravenous injection of Xueshuantong,and the experimental group was given intravenous injection of 0.6 g of gastrodin on the basis of thrombotong,and both groups were treated for 15 days.The UCLA-DDQ and VVAS scores were used to evaluate the treatment of vertigo symptoms before and after intervention in the two groups.Serum homocysteine(Hcy),endothelin-1(ET-1)and nitric oxide(NO)were detected in the two groups to evaluate vascular endothelial function.The levels of inflammation were assessed by measuring serum high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor(TNF-α)and interleukin-6(IL-6)concentrations.Color Doppler ultrasound system was used to record the mean blood flow velocity of the basilar artery,left vertebral artery and right vertebral artery.Results A total of 96 PCIV patients were included in the study,with 48 cases in each group.After treatment,the scores of UCLA-DQ and VVAS in the experimental group were lower than those in the control group(P<0.05),and the blood Hcy,ET-1,hs-CRP,TNF-αand IL-6 levels in the experimental group were lower than those in the control group(P<0.05),but the NO level was higher than that in the control group(P<0.05),and the mean blood flow velocity of basilar artery,left vertebral artery and right vertebral artery in the experimental group was higher than that in the control group(P<0.05).Conclusion Xueshuantong combined with gastrodin can significantly improve vertigo symptoms,protect vascular endothelial function,inhibit inflammatory factors and promote the improvement of cerebral hemodynamic indexes in PCIV patients.
作者
施盈盈
顾卫卫
SHI Yingying;GU Weiwei(Department of Pharmacy,Qidong People's Hospital,Nantong 226200,Jiangsu Province,China)
出处
《中国药师》
CAS
2024年第3期447-454,共8页
China Pharmacist
关键词
后循环缺血性眩晕症
天麻素注射液
血管内皮功能
炎症因子
Posterior circulation ischemic vertigo
Gastrodin injection
Vascular endothelial function
Inflammatory factor
作者简介
通信作者:顾卫卫,硕士,主管药师,Email:13606284396@163.com。
