摘要
目的探讨银杏叶提取物联合天麻素注射液对血管源性眩晕患者动脉血流速度、血管内皮功能及溶血磷脂酸(LPA)、酸性磷脂(AP)水平的影响。方法选取2018年6月—2019年6月西安医学院第二附属医院神经内科收治的血管源性眩晕患者104例,按随机数字表法将其分为对照组与观察组,各52例。对照组给予天麻素注射液治疗,观察组给予银杏叶提取物联合天麻素注射液,均治疗2周。观察2组临床疗效,治疗前后动脉血流速度(椎基底动脉、左侧椎动脉、右侧椎动脉血流速度)、血管内皮功能[内皮素-1(ET-1)、一氧化氮(NO)、血管性血友病因子(vWF)、血栓调节蛋白(TM)]及LPA、AP水平,记录不良反应发生情况。结果观察组总有效率高于对照组(90.38%vs.75.00%,χ~2=4.499,P=0.034)。与治疗前比较,2组治疗2周后椎基底动脉、左侧椎动脉、右侧椎动脉血流速度均升高,且观察组高于对照组(t/P=9.259/0.000, 8.257/0.000, 10.128/0.000)。与治疗前比较,2组治疗2周后ET-1、vWF、TM降低,NO升高,且观察组ET-1、vWF、TM较对照组降低,而NO较对照组升高(t/P=5.537/0.000, 9.082/0.000,7.346/0.000, 3.502/0.000)。与治疗前比较,2组治疗2周后LPA、AP降低,且观察组较对照组降低(t/P=5.941/0.000,8.920/0.000)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论银杏叶提取物联合天麻素注射液治疗血管源性眩晕可提高临床疗效,有效改善患者动脉血流速度、血管内皮功能和LPA、AP水平,安全性佳,具有较好的临床应用价值。
Objective To investigate the effect of Ginkgo biloba extract combined with gastrodin injection on arterial blood flow velocity,vascular endothelial function,lysophosphatidic acid(LPA)and acid phospholipid(AP)levels in patients with vascular vertigo.Methods 104 patients with vasogenic vertigo admitted to the Second Affiliated Hospital of Xi’an Medical College from June 2018 to June 2019 were selected.The patients were divided into observation group and control group by number table method,52 cases in each group.The observation group was given Ginkgo biloba extract combined with gastrodin injection,and the control group was given gastrodin injection for 2 weeks.The clinical effect,arterial blood flow velocity[right vertebral artery,left vertebral artery,vertebrobasilar artery blood flow velocity],endothelial function[endothelin-1(ET-1),nitric oxide(NO),von Willebrand factor(vWF),thrombomodulin(TM)],LPA and AP levels were compared between the two groups.Results The total effective rate of the observation group was 90.38%,which was higher than 75.00%of the control group(χ2=4.499,P=0.034).After 2 weeks of treatment,the blood flow velocity of vertebrobasilar artery,left vertebrobasilar artery and right vertebrobasilar artery of the two groups after treatment were higher than those before treatment,and the observation group was higher than the control group(t/P=9.259/0.000,8.257/0.000,10.128/0.000).After 2 weeks of treatment,ET-1,TM and vWF were lower than those before treatment,and NO was higher than those before treatment(P<0.05).After treatment,compared with the control group,ET-1,vWF and TM in the observation group decreased,while NO increased(t/P=5.537/0.000,9.082/0.000,7.346/0.000,3.502/0.000).After treatment,LPA and AP of the two groups were lower than those before treatment,and the observation group was lower than the control group(t/P=5.941/0.000,8.920/0.000).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgo biloba extract combined with gastrodin injection in the treatment of vascular vertigo can improve the clinical effect,which can effectively improve the arterial blood flow velocity,vascular endothelial function and LPA,AP levels,with good safety,and it has a good clinical application value.
作者
刘欣
王晓芳
吴延佳
吉智
慧晶
Liu Xin;Wang Xiaofang;Wu Yanjia;Ji Zhi;Hui Jing(Department of Neurology,The Second Affiliated Hospital of Xi'an Medical College,Shaanxi Province,Xi'an 710038,China)
出处
《疑难病杂志》
CAS
2021年第4期363-367,共5页
Chinese Journal of Difficult and Complicated Cases
基金
陕西省卫生健康科研项目(2018C0326)。
关键词
血管源性眩晕
银杏叶提取物
天麻素注射液
动脉血流速度
血管内皮功能
溶血磷脂酸
酸性磷脂
Vascular vertigo
Ginkgo biloba extract injection
Gastrodin injection
Arterial blood flow velocity
Vascular endothelial function
Lysophosphatidic acid
Acid phospholipid
作者简介
通信作者:吴延佳,E-mail:442903794@qq.com。