摘要
目的:探讨天麻素注射液联合乌司他丁治疗动脉瘤性蛛网膜下腔出血(aSAH)患者的临床疗效及对患者血清炎症因子、血管内皮功能等的影响。方法:选取2021年2月~2022年2月期间某院收治的80例aSAH患者作为研究对象,采用随机数字表法分为对照组和观察组,每组40例。所有患者于发病72h内给予显微开颅夹闭术或血管内栓塞介入治疗,术后给予止血、抗感染等常规治疗,对照组在常规治疗基础上给予注射用乌司他丁,观察组在对照组基础上加用天麻素注射液。比较两组患者血清炎症因子[白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、血管内皮功能[降钙素基因相关肽(CGRP)、内皮素-1(ET-1)及血管内皮生长因子(VEGF)]、神经功能[神经元特异性烯醇酶(NSE)、S100钙结合蛋白B(S100B)]、临床疗效及不良反应发生情况。结果:治疗后,两组患者血清IL-6、IL-8及TNF-α水平均降低(P<0.05),且观察组低于对照组(P<0.05);血浆CGRP水平均升高(P<0.05),且观察组高于对照组(P<0.05);ET-1、VEGF水平均降低(P<0.05),且观察组低于对照组(P<0.05);NSE、S100B水平均降低(P<0.05),且观察组低于对照组(P<0.05)。观察组患者临床总有效率(92.50%)高于对照组(75.00%,P<0.05);两组患者不良反应总发生率比较无统计学差异(P>0.05)。结论:天麻素注射液联合乌司他丁治疗aSAH患者临床疗效较好,可有效缓解炎症反应,改善血管内皮功能,调节神经功能,且未增加不良反应的发生风险。
Objective:To investigate the clinical efficacy of gastrodin injection combined with ulinastatin in the treatment of aneurysmal subarachnoid hemorrhage(aSAH)and its influence on serum inflammatory factors and vascular endothelial function.Methods:A total of 80 patients diagnosed with aSAH and admitted to a hospital between February 2021 and February 2022 were selected for this study.They were assigned into a control group and an observation group by random number table method,each consisting of 40 cases.Patients underwent microcraniotomy or endovascular embolization within 72 hours of onset,followed by routine postoperative care including hemostasis and infection prevention.The control group received ulinastatin for injection in addition to routine treatment,while the observation group received gastrodin injection on the basis of control group.The serum inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],vascular endothelial function[calcitonin gene-related peptide(CGRP),endothelin-1(ET-1),vascular endothelial growth factor(VEGF)],nerve function[neuron-specific enolase(NSE),S100 calcium binding protein B(S100B)],clinical efficacy and adverse reactions were compared between the two groups.Results:Following treatment,the serum levels of IL-6,IL-8,and TNF-αdecreased in both groups(P<0.05),with the observation group showing lower levels than the control group(P<0.05).Plasma CGRP levels increased in both groups(P<0.05),with the observation group showing higer levels than the control group(P<0.05).ET-1 and VEGF levels decreased in both groups(P<0.05),with the observation group showing lower levels than the control group(P<0.05).NSE and S100B protein levels also decreased in both groups(P<0.05),with the observation group exhibiting lower levels than the control group(P<0.05).The total effective treatment rate in the observation group(92.50%)was higher than that in the control group(75.00%,P<0.05).There was no statistically significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of gastrodin injection and ulinastatin demonstrates significant clinical efficacy in the treatment of aSAH patients.This combination effectively alleviates inflammation,enhances vascular endothelial function,regulates nervous function,and does not elevate the risk of adverse reactions.
作者
张翼
党少辉
赵征
马戈
张婷
ZHANG Yi;DANG Shao-hui;ZHAO Zheng;MA Ge;ZHANG Ting(Department of Neurosurgery,Dengzhou People's Hospital of Henan Province,Dengzhou 474150,China;Department of Neurology,Dengzhou People's Hospital of Henan Province,Dengzhou 474150,China;Department of Neurosurgery,Henan Provincial People's Hospital,Zhengzhou 450000,China)
出处
《中国合理用药探索》
CAS
2024年第3期1-7,共7页
Chinese Journal of Rational Drug Use
关键词
乌司他丁
天麻素注射液
动脉瘤性蛛网膜下腔出血
炎症反应
血管内皮功能
ulinastatin
gastrodin injection
aneurysmal subarachnoid hemorrhage
inflammatory reaction
vascular endothelial function
作者简介
张翼,男,副主任医师,专业方向:神经外科。E-mail:zhangyi221008@163.com。
