摘要
目的 探讨改良琼脂包埋法在胸腹腔积液良恶性鉴别诊断中的应用价值。方法 选取2020年1月至2022年12月赣州市肿瘤医院收治的180例胸腹腔积液患者作为研究对象,收集患者的胸腹腔积液,制备成细胞涂片及改良琼脂包埋法的石蜡包埋切片。以病理学结果为“金标准”,对比两组检验方法对胸腹腔积液阳性(恶性)检测的灵敏度、特异性。结果 100例胸腔积液中,共有良性胸腔积液42例,阳性胸腔积液58例;80例腹腔积液中,良性腹腔积液21例,阳性腹腔积液59例。改良琼脂包埋法检出阳性胸腔积液54例,阳性腹腔积液51例;细胞涂片法检出阳性胸腔积液48例,阳性腹腔积液47例。改良琼脂包埋法诊断胸腔积液阳性的灵敏度、特异性高于细胞涂片法,差异有统计学意义(P<0.05)。改良琼脂包埋法诊断腹腔积液阳性的灵敏度、特异性高于细胞涂片法,差异有统计学意义(P<0.05)。两种诊断方法的病理组织学分型中腺癌的发生率均最高,分别为54.00%、53.25%。结论改良琼脂包埋法的石蜡包埋切片对良恶性胸腹腔积液有较高的鉴别诊断价值,其灵敏度、特异性均较高,对病理学分型有较好的指导作用。
Objective To explore the value of modified agar embedding method in the differential diagnosis of benign and malignant thoracoabdominal effusion.Methods A total of 180 patients with benign and malignant thoracoabdominal effusion admitted to Ganzhou Cancer Hospital from January 2020 to December 2022 were selected as research objects.The patients' thoracoabdominal effusion was collected,and cell smear and paraffin-embedded section of modified agar embedding method were prepared.The sensitivity and specificity of the two test methods for positive(malignant) detection of thoracoabdominal effusion were compared with the pathological results as the "gold standard".Results There were 42 benign pleural effusions and 58 positive pleural effusions among 100 cases.Of the 80 cases of peritoneal effusion,21 were benign and 59 were positive.The modified agar embedding method detected positive pleural effusion in 54 cases and positive abdominal effusion in51 cases.There were 48 positive pleural effusion and 47 positive peritoneal effusion by cell smear.The sensitivity and specificity of the modified agar embedding method in the diagnosis of positive pleural effusion were higher than those of the cell smear method,and the differences were statistically significant(P<0.05).The sensitivity and specificity of the modified agar embedding method in the diagnosis of positive abdominal effusion were higher than those of the cell smear method,and the differences were statistically significant(P<0.05).The incidence of adenocarcinoma was the highest in the pathological tissue types of the two diagnostic methods,54.00% and 53.25%,respectively.Conclusion The paraffin embedded section with modified agar embedding method has a high value in differential diagnosis of benign and malignant pleuroperitoneal effusion,its sensitivity and specificity are high,and it has a good guiding effect on pathological classification.
作者
李慧娟
刘莉
廖伟莲
李荣
LI Huijuan;LIU Li;LIAO Weilian;LI Rong(Department of Pathology,Ganzhou Cancer Hospital,Jiangxi Province,Ganzhou 341000,China)
出处
《中国当代医药》
2023年第36期141-144,共4页
China Modern Medicine
基金
江西省赣州市科技计划项目(GZ2021ZSF343)。
关键词
改良琼脂包埋法
胸腹腔积液
良恶性
诊断效能
Modified agar embedding method
Thoracoabdominal effusion
Benign and malignant
Diagnostic effectiveness
