摘要
目的:探讨布地奈德与特布他林雾化吸入联合哌拉西林钠治疗小儿支气管肺炎的效果。方法:选取2021年1月—2023年9月峡江县人民医院诊疗的66例支气管肺炎患儿,通过红蓝双色球法随机分为对照组与观察组,各33例。对照组给予患儿静脉滴注哌拉西林钠治疗,观察组给予患者布地奈德与特布他林雾化吸入联合哌拉西林钠治疗。比较两组临床效果、不良反应发生情况及治疗前后血清学指标[血清转化生长因子-β_(1)(TGF-β_(1))、降钙素原(PCT)、C反应蛋白(CRP)]、免疫功能[免疫球蛋白(Ig)A、IgG、IgM]。结果:观察组总有效率为96.97%,高于对照组的75.76%(P<0.05);观察组TGF-β_(1)、PCT、CRP水平低于对照组,IgA、IgG、IgM高于对照组(P<0.05);观察组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:支气管肺炎患儿雾化吸入布地奈德与特布他林联合哌拉西林钠治疗效果显著,可显著改善血清学指标、免疫功能,安全性较高。
Objective:To explore the therapeutic effect of budesonide and terbutaline nebulized inhalation combined with piperacillin sodium in the treatment of children bronchial pneumonia.Methods:A total of 66 children with bronchial pneumonia treated in Xiajiang County People’s Hospital from January 2021 to September 2023 were randomly divided into control group and observation group by red and blue ball method,with 33 children in each group.The children were given piperacillin sodium for injection treatment in the control group,and patients were given the addition of budesonide and terbutaline nebulized inhalation combined with piperacillin sodium for injection treatment in the observation group.The clinical effects,adverse reactions,serological indexes[serum transforming growth factor-β_(1)(TGF-β_(1)),procalcitonin(PCT),C-reactive protein(CRP)]and immune function[immunoglobulin(Ig)A,IgG,IgM]before and after treatment were compared between the two groups.Results:The total effective rate of the observation group was 96.97%,which was higher than 75.76%of the control group(P<0.05).The levels of TGF-β_(1),PCT and CRP in the observation group were lower than those in the control group,and the levels of IgA,IgG and IgM were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion:Nebulized inhalation of budesonide and terbutaline combined with piperacillin sodium in children with bronchial pneumonia has a significant effect,which can significantly improve serological indicators and immune function,and has high safety.
作者
曾细根
熊桂兰
刘建林
ZENG Xigen;XIONG Guilan;LIU Jianlin(Department of pediatrics,Xiajiang County People’s Hospital,Xiajiang 331400,Jiangxi,China;Department of Internal Medicine,Xiajiang County People’s Hospital,Xiajiang 331400,Jiangxi,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第12期2169-2172,共4页
Chinese Journal of Drug Abuse Prevention and Treatment
基金
江西省吉安市指导性科技计划项目(编号:吉市科计字[2023]10号)。
关键词
布地奈德
特布他林
注射用哌拉西林钠
小儿支气管肺炎
Budesonide
Terbutaline
Piperacillin sodium for injection
Children bronchial pneumonia
作者简介
曾细根(1971年9月-),男,汉族,江西峡江人,本科,主治医师,主要研究方向:儿科常见疾病;通信作者:刘建林(1968年6月-),男,汉族,江西峡江人,本科,主任医师,主要研究方向:儿科常见疾病及神经系统疾病。
