摘要
痛风是一种由体内尿酸水平升高引起的代谢障碍,导致尿酸盐在关节中沉积,引发如痛风性关节炎(GA)等症状。这种关节炎表现为急性炎症、关节疼痛、红肿和发热,常见于大拇指基部。但GA并非痛风的唯一表现,痛风本身是更广泛的代谢紊乱,可能引发多种并发症。免疫细胞包括先天性免疫细胞和适应性免疫细胞,两者在免疫系统中协同完成对外来物质的识别和清除,在GA的发病过程中具有重要作用。因此,针对免疫细胞的治疗策略有望成为痛风治疗的新方向。治疗痛风相关各类靶向药物具有明显不良反应,易对肝肾及胃肠道形成损害。中医药因其疗效显著、不良反应少和患者依从性高等独特优势在预防和治疗痛风方面受到广泛认可。随着研究的不断深入,中医药干预免疫细胞治疗GA成为新的热点。本研究系统综述了先天免疫细胞和适应性免疫细胞在GA中作用机制的最新研究进展,主要以中药单体、中药复方和针灸作为切入点,进一步阐述中医药通过介导免疫细胞治疗GA的研究现状,旨在为今后以中医药方法干预免疫细胞治疗GA提供理论支持与治疗方向。
Gout is a metabolic disorder characterized by elevated levels of uric acid in the body,leading to the deposition of urate crystals in joints and subsequent symptoms such as gouty arthritis(GA).This form of arthritis is marked by acute inflammation,joint pain,redness,and fever,frequently affecting the base of the big toe.However,gouty arthritis is not the sole manifestation of gout,which is part of a broader metabolic dysregulation potentially resulting in various complications.Immune cells,including innate and adaptive immune cells,play an important role in the pathogenesis of GA.Therefore,treatment strategies targeting immune cells are expected to become a new direction for gout treatment.Targeted drugs related to gout have significant side effects and are prone to damage to the liver,kidneys,and gastrointestinal tract.Traditional Chinese medicine is widely recognized in the prevention and treatment of gout due to its unique advantages of significant therapeutic effect,low adverse reactions,and high patient compliance.With the deepening of exploration,traditional Chinese medicine intervention in immune cell therapy for GA has become a new hot topic.This article systematically reviewed the latest research progress in the mechanism of action of innate immune cells and adaptive immune cells in gout,and taking Chinese medicine monomer,Chinese medicine compound and acupuncture and moxibustion as the entry point,further elaborated the research status of the treatment of gout through Chinese medicine mediating immune cells,and to provid theoretical support and treatment direction for Chinese medicine intervention of immune cells in the treatment of gout in the future.
作者
邵子晨
李华南
黄鑫
胡烈奎
孙伟康
陈扬
吴东雨
SHAO Zichen;LI Huanan;HUANG Xin;HU Liekui;SUN Weikang;CHEN Yang;WU Dongyu(Jiangxi University of Chinese Medicine,Jiangxi Nanchang 330004,China;Affiliated Hospital of Jiangxi University of Chinese Medicine,Jiangxi Nanchang 330006,China)
出处
《中国医药导刊》
2023年第11期1117-1124,共8页
Chinese Journal of Medicinal Guide
基金
国家自然科学基金资助项目(项目编号:82060871,项目名称:基于肠菌轴探讨痛风清消方调控肠道菌群失衡并湿热证GA大鼠TLRs-MyD88-NF-κB信号通路的机制研究,项目编号:81860857,项目名称:痛风清消方调控痛风性关节炎自行消散及基于TGF-β1信号通路的中性粒细胞外捕作用研究)
2023年江西省科技专项资金项目(项目编号:20232ACB206051,项目名称:基于顺次电离直接质谱分析技术探讨痛风清消方调控湿热证痛风性关节炎大鼠骨代谢失衡的机制研究)
中医优势专病专科项目[项目编号:赣中医药综合字(2022)4号,项目名称:痛风]
江西省中医药管理局重点研究室、临床研究基地(第三批)建设项目[项目编号:赣中医药科教字(2022)8号,痹证重点研究室]。
关键词
免疫细胞
痛风性关节炎
机制
中医药
Immune cells
Gouty arthritis
Mechanism
Traditional Chinese medicine
作者简介
邵子晨,男,硕士,研究方向:中医骨伤疾病的研究。E-mail:1119899361@qq.com;通讯作者:李华南,女,博士,教授,主任中医师,研究方向:慢性筋骨疾病的研究。E-mail:20086170@jxutcm.edu.cn。
