摘要
目前,全球范围内正面临着高尿酸血症和痛风患病率持续上升的趋势,且高尿酸血症与慢性肾病、高血压、肥胖、2型糖尿病和动脉粥样硬化性心脏病等疾病的发生发展密切相关。然而,至今为止,此类疾病及其并发症的发病机制尚未完全阐明,新药的研发也存在一定的局限性和迟滞性。其重要原因在于国内外现有的高尿酸血症和痛风模型制备方法众多,仍未形成统一的标准,且绝大多数模型在血尿酸水平的持续性、稳定性等方面存在一定不足。本文现从高尿酸血症和痛风性关节炎造模动物的选择、模型制备方法和主要内脏的组织病理学变化等方面展开讨论,以期为高尿酸血症和痛风的动物模型制备,以及发病机制研究提供更多参考。
At the present time,we are facing an increasing prevalence of hyperuricemia and gout worldwide.Worryingly,hyperuricemia is closely associated with the development of chronic kidney disease,hypertension,obesity,type 2 diabetes,and atherosclerotic heart disease.The mechanism of these diseases and their complications have not been fully clarified,and there still exist some limitations and delays in the research into new drugs.One important obstacle is that there are too many types of hyperuricemia and gout animal models,and thus we are lacking a standard method.Moreover,most models have some shortcomings regarding the persistence and stability of blood uric acid levels.In this review,we discuss the availability of animal models of hyperuricemia and gouty arthritis,the method of model establishment,and the histopathological changes in major visceral organs,to provide a detailed reference for the establishment of animal models and the study of pathogenesis.
作者
程雅欣
李佳
CHENG Yaxin;LI Jia(Department of Endocrinology,General Hospital of Southern Theater Command,PLA,Guangzhou 510010;China.2.Guangzhou University of Chinese Medicine,Guangzhou 510405)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2023年第2期251-256,共6页
Acta Laboratorium Animalis Scientia Sinica
基金
2021年度南部战区总医院科技计划课题(2021NZA001)。
作者简介
程雅欣(1997—),女,硕士,研究方向:内分泌代谢病发病机制。Email:cyx961126@163.com;通信作者:李佳,女,博士,副主任医师,硕士生导师,研究方向:糖尿病及其并发症发病机制。Email:gdnflj@126.com。
