摘要
目的 探讨血清结缔组织生长因子(CTGF)、白介素-6(IL-6)、松弛素(RLN)水平与产后盆底功能康复效果的关系。方法 选取2020年12月至2022年12月海口市妇幼保健院产后康复科收治的150例产后盆底功能障碍(PFD)患者作为研究对象,对研究对象进行盆底肌功能训练联合生物反馈治疗,持续治疗6周后按照MLD B42盆底表面肌功能评分将患者分为有效组(n=103)和无效组(n=47),采用多因素Logistic回归分析产后盆底功能康复效果不佳的独立影响因素;采用受试者工作特征曲线(ROC)评估血清CTGF、IL-6、RLN检测对产后盆底功能康复效果的诊断效能。结果 两组的产次、分娩方式、新生儿出生体重、血清CTGF、IL-6、RLN水平比较,差异具有统计学意义(χ^(2)=11.687、3.838、10.371,t=42.549、34.995、2.021,P<0.05)。多因素Logistic回归分析结果显示,产次>1次、新生儿出生体重≥3 500 g、CTGF、IL-6、RLN为PFD患者产后盆底功能康复效果的独立危险因素(P<0.05)。ROC曲线结果显示,血清CTGF、IL-6、RLN单独检测诊断产后盆底功能康复效果的曲线下面积(AUC)为0.965、0.912、0.598。结论 血清CTGF、IL-6、RLN与孕妇产后盆底功能康复效果密切相关,且血清CTGF、IL-6单独检测对产后盆底功能康复效果具有较高的诊断效能,值得推广使用。
Objective To investigate the relationship between the levels of serum connective tissue growth factor(CTGF),interleukin-6(IL-6)and relaxin(RLN)and the effect of postpartum pelvic floor function rehabilitation.Methods 150 patients with postpartum pelvic floor dysfunction(PFD)admitted to the postpartum Rehabilitation Department of Maternal and Child Health Hospital of Haikou City from December 2020 to December 2022 were selected as the research objects.Pelvic floor muscle function training combined with biofeedback therapy was performed on the subjects.After 6 weeks of continuous treatment,the patients were divided into the effective group(n=103)and the ineffective group(n=47)according to MLD B42 pelvic floor surface muscle function score.Multivariate Logistic regression was used to analyze the independent influencing factors of poor postpartum pelvic floor function rehabilitation.The receiver operating characteristic curve(ROC)was used to evaluate the diagnostic efficacy of serum CTGF,IL-6 and RLN alone for postpartum pelvic floor functional rehabilitation.Results There were statistically significant differences between the observation group and the control group in terms of delivery times,delivery mode,newborn birth weight,serum levels of CTGF,IL-6 and RLN(X^(2)=11.687,3.838,10.371,t=42.549,34.995,2.021,P<0.05).Multiple Logistic regression analysis showed that number of births>1,birth weight≥3500 g,CTGF,IL-6 and RLN were independent risk factors for postpartum pelvic floor functional rehabilitation in PFD patients(P<0.05).The ROC curve results showed that the area under the curve(AUC)of serum CTGF,IL-6 and RLN were 0.965,0.912 and 0.598 respectively.Conclusion Serum CTGF,IL-6 and RLN are closely related to the effect of postpartum pelvic floor functional rehabilitation in pregnant women,and serum CTGF and IL-6 have high diagnostic efficacy for postpartum pelvic floor functional rehabilitation,which is worthy of popularization.
作者
符剑花
周冰
冯永洪
陈才菊
FU Jianhua;ZHOU Bing;FENG Yonghong;CHEN Caiju(Department of Postpartum Rehabilitation,Haikou Maternal and Child Health Hospital,Haikou,Hainan,China,570102;Department of Obstetrics,Haikou Maternal and Child Health Care Hospital,Haikou,Hainan,China,570102;Department of Neonatology,Haikou Maternal and Child Health Care Hospital,Haikou,Hainan,China,570102)
出处
《分子诊断与治疗杂志》
2023年第10期1676-1679,共4页
Journal of Molecular Diagnostics and Therapy
基金
海南省卫生健康行业科研项目(22A200133)。
作者简介
通信作者:符剑花,E⁃mail:fujianhua08982022@163.com。
