自拟慢阻肺康复方对肺脾气虚型稳定期慢性阻塞性肺疾病的临床疗效观察被引量：8

Clinical Observation on the Effect of Self-Designed Chronic Obstructive Pulmonary Disease Recovery Formula on Stable Chronic Obstructive Pulmonary Disease of Lung and Spleen Qi Deficiency Type

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摘要目的:观察自拟慢阻肺康复方治疗肺脾气虚型稳定期慢性阻塞性肺疾病的临床疗效及其对患者血清炎症因子与肺功能的影响。方法:将符合纳入标准的106例肺脾气虚型稳定期慢性阻塞性肺疾病患者依据随机数字表随机分为西医治疗组以及中医方剂组,每组各53例。西医治疗组采用沙美特罗替卡松粉吸入剂治疗,中医方剂组患者在西医治疗组方案基础上结合自拟慢阻肺康复方治疗。观察比较两组患者的临床疗效、治疗前后血清白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平、中医证候积分、圣乔治呼吸问卷(SGRQ)评分、肺功能指标和不良反应发生情况。结果:中医方剂组临床总有效率94.34%(50/53)优于西医治疗组总有效率79.25%(42/53),差异具有统计学意义(P <0.05);治疗前,两组患者IL-6、TNF-α、中医证候积分、SGRQ评分、用力肺活量(FVC)及第1秒用力呼气容积(FEV1)、FEV1/FVC等肺功能指标比较,差异无统计学意义(P> 0.05);治疗后,两组患者IL-6、TNF-α、中医证候总积分、SGRQ评分及FVC、FEV1、FEV1/FVC等肺功能指标均显著改善,且中医方剂组优于西医治疗组,差异具有统计学意义(P <0.05);西医治疗组出现1例恶心,中医方剂组出现1例心悸,不良反应发生率比较差异无统计学意义(P> 0.05)。结论:自拟慢阻肺康复方治疗肺脾气虚型稳定期慢性阻塞性肺疾病可较好改善患者症状和肺功能情况,且安全可行。 Objective:To observe clinical effects of self-designed chronic obstructive pulmonary disease COPD recovery formula on stable chronic obstructive pulmonary disease of lung and spleen qi deficiency type and on serum inflammatory factors and lung function of the patient.Methods:106 patients with stable(COPD)of lung and spleen deficiency type who met the inclusion criteria were randomly divided into a Western medicine treatment group and a Chinese medicine formula group based on a random number table,with 53 patients in each group.Patients in Western medicine treatment group were treated with salmeterol and fluticasone powder inhalation.Patients in traditional Chinese medicine formula group underwent the same treatment in addition to self-designed COPD recovery formula.Clinical efficacy,changes before and after treatment of serum interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)levels,score changes of traditional Chinese medicine syndrome,score changes of St.George's Respiratory Questionnaire(SGRQ),and changes of pulmonary function indexes,and adverse reactions were observed.Results:The therapeutic effect of Chinese medicine formula group(94.34%)was superior to that of Western medicine treatment group(79.25%,P<0.05).Before the treatment,IL-6,TNF-α,score of TCM syndrome,SGRQ score,forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC and other pulmonary function indexes were compared between the two groups,and there was no statistical difference(P>0.05).While after the treatment,IL-6,TNF-α,score of TCM syndrome,SGRQ score,forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC and other pulmonary function indexes were significantly improved in all groups.However,IL-6,TNF-α,total score of TCM syndrome,SGRQ score,FVC and FEV1,FEV1/FVC and other pulmonary function indexes in TCM formula group were improved more than those in Western medicine treatment group(P<0.05).A patient presented nausea in Western medicine group and a patient had palpitation in the traditional Chinese medicine group(P>0.05).Conclusion:The self-designed COPD recovery formula is effective in the treatment of stable COPD of lung and spleen qi deficiency type,can better improve the symptoms and pulmonary function of the patients,and is safe and feasible.

作者黄浦杨小静朱梦琪刘鑫 HUANG Pu;YANG Xiaojing;ZHU Mengqi;LIU Xin(Xuchang Central Hospital,Xuchang 461000,China)

机构地区许昌市中心医院

出处《中医药信息》 2023年第10期66-70,共5页 Information on Traditional Chinese Medicine

基金河南省科学技术厅项目(LHGJ20191401)。

关键词稳定期慢性阻塞性肺疾病肺脾气虚型自拟慢阻肺康复方沙美特罗替卡松粉吸入剂疗效肺功能不良反应 Stable chronic obstructive pulmonary diseases Lung and spleen qi deficiency type Self-designed chronic obstructive pulmonary disease recovery formula Salmeterol fluticasone powder inhalant Curative effect Lung function Adverse reaction

分类号 R259 [医药卫生—中西医结合]

作者简介第一作者:黄浦(1986-),女,硕士,副主任中医师,主要研究方向:中医药治疗老年呼吸、消化系统疾病。