摘要
多囊卵巢综合征(Polycystic Ovary Syndrome, PCOS)是常见的生殖内分泌代谢紊乱性疾病,早期可致月经异常、不孕症、不良孕产及糖耐量减低等,若不及时干预,远期可并发代谢异常性疾病及心理疾病,严重影响着女性生理生育、生活质量及心理健康。其具有临床表现多样性,主要包括多毛、痤疮、肥胖等,致病因素复杂性、发病机制不清等特点。肠道作为机体的重要器官,被称为“人体的第二个大脑”,肠内菌群的种类、数量可以通过神经、内分泌、免疫等来参与人体代谢活动,肠道菌群及其代谢产物紊乱可破坏机体肠道屏障,增加肠道通透性,诱发慢性低度炎症反应,从而促进各系统疾病的发生。人体和动物模型研究均发现PCOS患者存在肠道菌群失调,具体表现为肠道菌群的整体多样性及特定菌属丰度的改变。中医认为PCOS是因“肾-天癸-冲任-胞宫”生殖轴功能紊乱而引发。中医治疗包括中医药及针灸等方法可通过调和脾胃肠道,对肠道微生态分布和结构起到调节作用,从而纠正代谢紊乱,因此调节肠道菌群可能是治疗PCOS的潜在领域。文章将阐述肠道菌群与PCOS相关性,有助于寻找PCOS病因病机及为靶向肠道菌群治疗PCOS提供新的切入点,以期通过纠正肠道微生态紊乱,从而为治疗PCOS患者的症状,防治PCOS并发症及改善PCOS患者的生活质量提供临床指导。
Polycystic ovary syndrome is a common reproductive endocrine metabolic disorder,which can cause menstrual abnormalities,infertility,poor pregnancy and impaired glucose tolerance in the early stage,and if not intervened in time,it can be complicated by metabolic disorders and psychological diseases in the long term.It seriously affects women's physical fertility,quality of life and mental health.It has a variety of clinical manifestations,mainly including hirsutism,acne,obesity,etc.,complex pathogenic factors,unclear pathogenesis and other characteristics.As an important organ of the body,the intestine is known as the second brain of the human body,the type and number of intestinal flora can participate in human metabolic activities through nerves,endocrine,immunity,etc.,and the disorder of intestinal flora and its metabolites can destroy the intestinal barrier of the body,increase intestinal permeability,induce chronic low-grade inflammatory reactions,thereby promoting the occurrence of diseases of various systems.Both human and animal model studies have found that PCOS patients have intestinal dysbacteriosis,which is manifested by the overall diversity of intestinal flora and changes in the abundance of specific bacterial species.TCM believes that PCOS is caused by the dysfunction of the reproductive axis of kidney-Tiangui(天癸)-Chongren(冲任)-Baogong(胞宫).TCM treatment including TCM medicine and acupuncture can correct metabolic disorders by harmonizing the spleen,gastrointestinal tract,regulating the distribution and structure of the intestinal microbiome,so regulating the intestinal flora may be a potential area for the treatment of PCOS.This article will explain the correlation between intestinal flora and PCOS,which will help to find the etiology of PCOS and provide a new entry point for the treatment of PCOS by targeting intestinal flora,in order to treat the symptoms of PCOS patients,prevent and treat PCOS complications and improve the quality of life of PCOS patients by correcting intestinal microbiome disorders.
出处
《中医临床研究》
2023年第23期47-50,共4页
Clinical Journal Of Chinese Medicine
关键词
多囊卵巢综合征
肠道菌群
研究进展
慢性低度炎症
Polycystic ovary syndrome
Gut Microbiota
Research progress
Chronic low-grade inflammation
作者简介
苏比奴尔·阿不都克力木(1996-),女,在读硕士研究生,研究方向为中医妇科学;通讯作者:韩璐,教授,主任医师,硕士生导师,研究方向为中医妇科学。
