摘要
健康人肠道内生活着各种复杂的肠道微生物,其与宿主对疾病的易感性密切相关。正常的肠道微生物可对外来病原菌产生定植抗性,而抗生素的使用会影响肠道微生物的组成并改变肠道微环境,进而引起肠道微生态紊乱,导致病原菌的肠道感染,从而引发腹泻等疾病。本文对肠道微生态的概念和组成、肠道定植抗性的形成机制、抗生素对肠道微生态的影响及其治疗方法的研究进展进行综述,旨在为合理使用抗生素、研发更有效的恢复肠道微生态稳定的治疗方法提供理论参考。
There is a variety of gut microbiota in human body,which is closely associated with the health and disease.Normal gut microbiota can produce colonization resistance to pathogens.Antibiotics can affect the composition of gut microbiota and change the intestinal microenvironment,resulting in intestinal microecological disorders,which in turn cause intestinal pathogenic infections and other diseases.In this paper,the concept of intestinal microecology,the mechanism of intestinal colonization resistance,the effect of antibiotics on intestinal microecology,and the treatment methods were reviewed,aiming to provide the information for the rational use of antibiotics and the development of more effective treatment methods to maintain the stability of intestinal microecology.
作者
迟湘胤
林媛
蒋建东
CHI Xiang-yin;LIN Yuan;JIANG Jian-dong(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第8期1981-1987,共7页
Acta Pharmaceutica Sinica
基金
中国医学科学院医学与健康科技创新工程项目(2021-I2M-1-026,2021-I2M-JB-011)。
关键词
抗生素
肠道微生态
肠道菌群
定植抗性
治疗
antibiotics
intestinal microecology
gut microbiota
colonization resistance
treatment
作者简介
通讯作者:林媛,Tel:86-10-63017906,E-mail:linyuan@imm.ac.cn;通讯作者:蒋建东,jiang.jdong@163.com。
