摘要
目的 探究急性脑梗死应用银杏达莫联合依达拉奉右莰醇治疗的临床疗效。方法 选取2020年6月-2022年12月邳州市中医院收治的78例急性脑梗死患者为研究对象,以随机数表法分为两组,对照组39例应用依达拉奉右莰醇治疗,研究组39例应用银杏达莫联合依达拉奉右莰醇治疗,对比两组疗效、不良反应、血液流变指标、神经功能缺损评分、日常生活能力评分及炎性因子水平。结果 研究组总有效率高于对照组(94.87%vs 79.49%),差异有统计学意义(χ^(2)=4.129,P<0.05)。治疗前,两组血液流变指标、神经功能缺损评分、功能恢复评分及炎性因子水平比较,差异无统计学意义(P>0.05)。治疗后,研究组红细胞沉降率、血浆黏度水平均较对照组更低,差异有统计学意义(P<0.05)。研究组神经功能缺损评分为(5.65±0.68)分,较对照组的(6.29±1.07)分更低,功能恢复评分为(3.68±0.63)分,较对照组的(3.22±0.58)分更高,差异有统计学意义(t=3.153、3.355,P<0.05)。研究组白介素-6、肿瘤坏死因子水平比对照组更低,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 银杏达莫联合依达拉奉右莰醇用于急性脑梗死治疗,患者血液流变学及神经功能均得到极大缓解,炎性因子水平降低,日常生活能力提升,安全可靠。
Objective To investigate the clinical efficacy of acute cerebral infarction treated with Ginkgundamo com⁃bined with edaravone and dexborneol.Methods 78 patients with acute cerebral infarction admitted to Pizhou Hospital of Traditional Chinese Medicine from June 2020 to December 2022 were selected as the research objects.They were divided into two groups by random number table.39 patients in the control group were treated with edaravone and dex⁃tranol,and 39 patients in the study group were treated with ginkgundamo combined with edaravone and dextranol.The efficacy,adverse reactions,hemorheological indicators,neurological deficit scores,fuctional recoveny scores,and lev⁃els of inflammatory factors of the two groups were compared.Results The total effective rate of the research group was higher than that of the control group(94.87%vs 79.49%),and the difference was statistically significant(χ^(2)=4.129,P<0.05).Before treatment,there was no statistically significant difference between the two groups in terms of blood rheol⁃ogy indicators,neurological deficit score,daily living ability score,and inflammatory factor levels(P>0.05).After treat⁃ment,the erythrocyte sedimentation rate and plasma viscosity level in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The neurological deficit score of the study group was(5.65±0.68)points,which was lower than the control group´s(6.29±1.07)points,and the fuctional recoveny score was(3.68±0.63)points,which was higher than the control group´s(3.22±0.58)points,and the difference was statistically significant(t=3.153,3.355,P<0.05).The levels of interleukin-6 and tumor necrosis factor in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).There was no sta⁃tistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ginkgundamo combined with edaravone and dexborneol for the treatment of acute cerebral infarction,the patients´blood rheology and neurological function were greatly relieved,the level of inflammatory factor was reduced,the abil⁃ity of daily life was improved,and it was safe and reliable.
作者
张楠
冯彦梅
ZHANG Nan;FENG Yanmei(Department of Cerebral Disease,Pizhou Hospital of Traditional Chinese Medicine,Pizhou,Jiangsu Province,221300 China)
出处
《系统医学》
2023年第11期181-184,共4页
Systems Medicine
关键词
银杏达莫
依达拉奉右莰醇
急性脑梗死
神经功能
生活能力
不良反应
Ginkgundamo
Edaravone and dexborneol
Acute cerebral infarction
Neurological function
Ability of daily life
Adverse effects
作者简介
张楠(1988-),女,本科,主治医师,主要从事脑病科临床工作;通信作者:冯彦梅(1972-),女,本科,主任医师,主要从事脑病科临床工作,E-mail:zn6562zn@163.com。
