摘要
目的 探讨多囊卵巢综合征(POCS)患者血清分泌型卷曲相关蛋白4(SFRP4)的表达与胰岛素抵抗(IR)的相关性。方法 选取2019年2月至2022年2月该院收治的172例PCOS患者作为研究对象,根据PCOS患者是否发生IR分为IR组(104例)和非IR组(68例),另选择61例健康体检女性志愿者为对照组。检测受试者血清SFRP4表达,分析血清SFRP4与POCS临床指标的相关性及血清SFRP4诊断POCS患者IR的价值。结果 IR组、非IR组血清SFRP4高于对照组,差异有统计学意义(P<0.05);IR组血清SFRP4高于非IR组,差异有统计学意义(P<0.05)。血清SFRP4水平与体重指数、卵泡数、卵巢体积、睾酮(T)、总胆固醇、空腹血糖、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数呈正相关(P<0.05)。FINS、血清SFRP4是PCOS患者IR的危险因素(P<0.05)。血清SFRP4诊断PCOS患者IR的曲线下面积为0.823(95%CI:0.757~0.877),灵敏度为81.73%,特异度为82.35%。结论 发生IR的PCOS患者血清SFRP4水平显著增高,且与T水平增高、糖脂代谢紊乱和IR有关,可作为PCOS患者IR的潜在指标。
Objective To investigate serum secreted frizzled-related protein 4(SFRP4) expression and insulin resistance(IR) in patients with polycystic ovary syndrome(POCS).Methods A total of 172 patients with PCOS admitted to a hospital from February 2019 to February 2022 were selected as the study objects,and divided into IR group(104 cases) and non-IR group(68 cases) according to whether PCOS patients developed IR,and 61 healthy female volunteers were selected as control group.Serum SFRP4 expression was detected,and the correlation between serum SFRP4 and clinical indicators of POCS was analyzed,as well as the value of serum SFRP4 in the diagnosis of IR in patients with POCS.Results Serum SFRP4 in IR group and non-IR group was higher than that in control group,the difference was statistically significant(P<0.05);Serum SFRP4 in IR group was higher than that in non-IR group,and the difference was statistically significant(P<0.05).Serum SFRP4 level was positively correlated with body mass index,follicle number,ovarian volume,testosterone(T),total cholesterol,fasting blood glucose,fasting insulin(FINS) and homeostasis model insulin resistance index(P<0.05).FINS and serum SFRP4 were risk factors for IR in patients with PCOS(P<0.05).The area under the curve of serum SFRP4 in the diagnosis of IR in PCOS patients was 0.823(95%CI:0.757-0.877),the sensitivity was 81.73%,and the specificity was 82.35%.Conclusion Serum SFRP4 level is significantly increased in PCOS patients with IR,which is related to T level,glucose and lipid metabolism disorder and IR,and can be used as a potential indicator of IR in PCOS patients.
作者
姚青
史琳茜
马海燕
潘懿
YAO Qing;SHI Linxi;MA Haiyan;PAN Yi(Department of Obstetrics and Gynecology,Yixing Traditional Chinese Medicine Hospital,Yixing,Jiangsu 214200,China)
出处
《国际检验医学杂志》
CAS
2023年第16期1925-1928,1933,共5页
International Journal of Laboratory Medicine
基金
江苏省科技厅面上项目(BK20181584)。
作者简介
姚青,女,主治医师,主要从事妇科内分泌研究;通信作者:潘懿,E-mail:xyc20120122@163.com。
