摘要
目的观察鱼腥草滴眼液超声雾化联合睑板腺按摩治疗睑板腺功能障碍(MGD)相关干眼的临床疗效。方法纳入2021年10月—2022年10月北京市隆福医院诊断为MGD相关干眼的患者120例(120只眼),随机分为观察组和对照组,各60例(60只眼)。对照组予生理盐水超声雾化联合睑板腺按摩治疗;观察组予鱼腥草滴眼液超声雾化联合睑板腺按摩治疗,共治疗4周,并分别于治疗前和治疗后测量受试者眼表疾病指数量表(OSDI)评分、泪膜破裂时间(BUT)、泪液分泌试验(SⅠT)、睑脂排出能力评分和睑板腺分泌物性状评分。结果2组治疗前OSDI、BUT、SⅠT、睑脂排出能力评分和睑板腺分泌物性状评分比较,差异均无统计学意义(P>0.05)。(1)OSDI评分:2组治疗后OSDI评分均较治疗前降低(t_(对照组)=26.130,t_(观察组)=22.580,均P=0.000)。治疗后观察组OSDI评分低于对照组(t=4.545,P=0.000),差异均有统计学意义。(2)BUT:2组治疗后BUT均较治疗前增加(t_(对照组)=7.808,t_(观察组)=11.020,均P=0.000)。治疗后观察组BUT高于对照组(t=3.908,P=0.000),差异均有统计学意义。(3)SⅠT:2组治疗后SⅠT均较治疗前增加(t_(对照组)=6.008,t_(观察组)=7.904,均P=0.000)。治疗后观察组SⅠT高于对照组(t=3.220,P=0.002),差异均有统计学意义。(4)睑脂排出能力评分:2组治疗后睑脂排出能力评分均较治疗前降低(t_(对照组)=6.061,t_(观察组)=5.269,均P=0.000),差异均有统计学意义。治疗后差异无统计学意义(P>0.05)。(5)睑板腺分泌物性状评分:治疗前后比较,2组治疗后睑板腺分泌物性状评分均较治疗前降低(t_(对照组)=4.139,t_(观察组)=6.119,均P=0.000)。治疗后观察组睑板腺分泌物性状评分低于对照组(t=3.844,P=0.000),差异均有统计学意义。(6)临床疗效:观察组总有效率(93.33%)高于对照组(80.00%),差异有统计学意义(χ^(2)=4.615,P=0.032)。结论临床上应用鱼腥草滴眼液超声雾化联合睑板腺按摩治疗MGD相关干眼,可以显著改善眼部的不适症状,提高睑板腺功能,促进泪液分泌,稳定泪膜,值得临床推广应用。
OBJECTIVE To observe the clinical efficacy of Houttuynia eye drops atomization combined with meibomian gland massage in the treatment of meibomian gland dysfunction(MGD)-related dry eyes.METHODS A total of 120 patients(120 eyes)diagnosed with MGD-related dry eyes at Beijing Longfu Hospital from October 2021 to October 2022 were randomly divided into the observation group(OG)and the control group(CG),with 60 patients(60 eyes)in each group.The control group was treated with normal saline ultrasound atomization combined with meibomian gland massage,while the observation group was treated with Houttuynia eye drops atomization combined with meibomian gland massage.Both groups were observed for four weeks.The subjects´ocular surface disease index(OSDI)scores,tear film breaking-up time(BUT),Schirmer I test(SⅠT),lipid ejection ability scores,and meibomian gland secretion trait scores were recorded before and after treatment.RESULTS There were no significant differences between the two groups in OSDI,BUT,SⅠT,eyelid fat excretion ability scores,and meibomian gland secretion trait scores before treatment(P>0.05).(1)OSDI:OSDI scores of both groups decreased after treatment when compared to those before treatment(t_(CG)=26.130,t_(OG)=22.580,both P=0.000).After treatment,when compared between the two groups,OSDI scores of the observation group were lower than those of the control group,and the differences were statistically significant(t=4.545,P=0.000).(2)BUT:Both groups showed an increase in BUT after treatment when compared to those before treatment(t_(CG)=7.808,t_(OG)=11.020,both P=0.000).After treatment,BUT in the observation group was longer than that in the control group,and the difference was statistically significant(t=3.908,P=0.000).(3)SⅠT:Both groups showed an increase in SⅠT after treatment when compared to those before treatment(t_(CG)=6.008,t_(OG)=7.904,both P=0.000).After treatment,the comparison between the two groups showed that the SⅠT in the observation group was longer than that in the control group,and the difference was statistically significant(t=3.220,P=0.002).(4)Lipid ejection ability scores:The scores of lipid ejection ability in both groups decreased after treatment when compared to those before treatment,and the differences were statistically significant(t_(CG)=6.061,t_(OG)=5.269,both P=0.000).After treatment,there were no statistically significant differences between the two groups(P>0.05).(5)Meibomian gland secretion trait scores:The meibomian gland secretion trait scores in both groups decreased after treatment when compared to those before treatment(t_(CG)=4.139,t_(OG)=6.119,both P=0.000).After treatment,the meibomian gland secretion trait scores in the observation group were lower than those in the control group,and the differences were statistically significant(t=3.844,P=0.002).(6)Clinical efficacy:The total effective rate of the observation group(93.33%)was higher than that of the control group(80.00%),and the difference was statistically significant(χ^(2)=4.615,P=0.032).CONCLUSIONS The clinical application of Houttuynia eye drops atomization combined with meibomian gland massage in the treatment of MGD-related dry eyes can significantly improve the ocular discomfort,improve the meibomian gland function,promote tear secretion,and stabilize the tear film,which is worthy of clinical application.
作者
褚文丽
李琦
赵海亮
刘伯温
CHU Wenli;LI Qi;ZHAO Hailiang;LIU Bowen(Beijing Longfu Hospital,Beijing 100010,China)
出处
《中国中医眼科杂志》
2023年第8期737-741,共5页
China Journal of Chinese Ophthalmology
关键词
干眼
鱼腥草滴眼液
超声雾化
睑板腺按摩
dry eye disease
Houttuynia eye drops
atomization
meibomian gland massage
作者简介
通讯作者:李琦,E-mail:qiqi199@sina.com。
