摘要
目的观察红宝石激光联合氨甲环酸治疗脂溢性角化病(SK)的临床疗效及其对患者性激素水平的影响。方法前瞻性选取2021年2月至2022年1月广安市人民医院收治的80例SK患者,所有患者按照1~80编号,1~40为观察组,41~80为对照组。观察组采用红宝石激光联合氨甲环酸治疗,对照组采用超脉冲CO_(2)激光治疗。记录两组患者治疗后恢复指标,比较两组患者治疗前后性激素[雌二醇、促卵泡成熟激素(FSH)、黄体生成激素(LH)]水平、生活质量改善情况、临床疗效和不良反应发生情况。结果观察组患者治疗次数、痂皮完全脱落时间、遗留红斑持续时间分别为(7.29±1.03)d、(11.45±1.22)d、(1.13±0.53)次,均明显短于对照组[(8.48±1.25)d、(14.67±1.43)d、(1.56±0.52)次],疼痛视觉模拟评分法(VAS)评分为(2.61±0.52)分,明显低于对照组[(3.74±0.57)分],差异均有统计学意义(P<0.05)。两组患者治疗后E2、FSH、LH水平较治疗前均明显降低,且观察组E2、FSH、LH水平分别为(189.28±16.61)pmol/mL、(13.59±2.20)U/L、(7.12±0.60)U/L,均显著低于对照组[(320.43±18.03)pmol/mL、(17.76±2.25)U/L、(8.60±0.37)U/L],差异均有统计学意义(P<0.05)。治疗后,两组患者各项生活质量评分明显低于治疗前,且观察组明显低于对照组,差异均有统计学意义(P<0.05)。观察组患者的治疗总有效率为95.0%,明显高于对照组(75.0%),差异有统计学意义(P<0.05)。观察组患者不良反应发生率(10.0%)与对照组(15.0%)相比,差异无统计学意义(P>0.05)。结论与超脉冲CO_(2)激光治疗相比,红宝石激光联合氨甲环酸治疗SK,可提高临床疗效,显著改善患者性激素水平及生活质量,有利于缓解疼痛、加快痂皮脱落,安全可靠,值得推广。
Objective To observe the clinical efficacy of ruby laser combined with tranexamic acid in the treatment of seborrheic keratosis(SK)and its influence on the level of sexual hormones in patients.Methods From Februar 2021 to January 2022,80 patients with SK in Guang'an People's Hospital were prospectively selected.All patients were numbered from 1 to 80,with 1 to 40 as the observation group and 41 to 80 as the control group.The observation group was treated with ruby laser combined with tranexamic acid,and the control group was treated with super pulse CO_(2) mode.The recovery indexes of the two groups were recorded,and the sexual hormone[estradiol,follicle-stimulating hormone(FSH),luteinizing hormone(LH)]level,quality of life improvement,clinical efficacy and adverse reactions of the two groups were compared before and after treatment.Results The times of treatment,the time of scab peeling off completely,the duration of erythema left in the observation group were(7.29±1.03)days,(11.45±1.22)days and(1.13±0.53)times,respectively,which were significantly shorter than those in the control group[(8.48±1.25)days,(14.67±1.43)days and(1.56±0.52)times],and the visual analogue scale(VAS)scores was(2.61±0.52)points,which were significantly lower than those in the control group[(3.74±0.57)points],and the differences were statistically significant(P<0.05).After treatment,the levels of estradiol,FSH and LH in the two groups were significantly lower than those before treatment,and the levels of estradiol,FSH and LH in the observation group were(189.28±16.61)pmol/mL,(13.59±2.20)U/L,(7.12±0.60)U/L,respectively,which were significantly lower than those in the control group[(320.43±18.03)pmol/mL,(17.76±2.25)U/L,(8.60±0.37)U/L],and the differences were statistically significant(P<0.05).The scores of quality of life in the two groups after treatment were significantly lower than those before treatment,and the scores in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group(95.0%)was statistically significantly higher than that of the control group(75.0%)(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group(10.0%)and the control group(15.0%)(P>0.05).Conclusion Compared with the ultra pulse CO_(2) mode treatment,the ruby laser combined with tranexamic acid treatment of SK can improve the clinical efficacy,significantly improve the patient's sex hormone level and quality of life,help relieve pain,speed up scab peeling,safe and reliable,and is worth promoting.
作者
杜佳
唐雪
刘利红
DU Jia;TANG Xue;LIU Li-hong(Medical Cosmetology Center,Guang'an People's Hospital,Guang'an Sichuan 638500,China;Department of Chinese Medicine,Guang'an People's Hospital,Guang'an Sichuan 638500,China)
出处
《临床和实验医学杂志》
2023年第9期999-1002,共4页
Journal of Clinical and Experimental Medicine
基金
四川省卫生和计划生育委员会科研课题(编号:17PJ090)。
作者简介
通讯作者:刘利红,E-mail:dku9089@163.com。
