摘要
目的探讨皮秒翠绿宝石点阵激光联合氨甲环酸治疗脂溢性角化病的疗效及其对性激素的影响。方法将自2017年3月至2019年1月收治的238例脂溢性角化病患者随机分为对照组和观察组,每组各119例。对照组采用超脉冲CO2激光治疗;观察组采用皮秒翠绿宝石点阵激光联合氨甲环酸治疗。各组均根据皮损部位及性质选用适宜能量治疗1次,治疗结束3个月后随访,比较两组在皮肤病生活质量评分(DLQI)及性激素水平(E2、FSH、LH)的差异,同时记录不良反应发生情况。结果对照组有效率为72.3%(86例),痊愈率为29.4%(35例);观察组有效率为78.2%(93例),痊愈率为58.0%(69例)。观察组1次治疗后的痊愈率显著优于对照组(P<0.001),两组之间有效率差异无统计学意义(P>0.05);观察组E2、FSH、LH较治疗前下降(P<0.05);两组患者DLQI评分均较治疗前下降(P<0.05),组间差异无统计学意义(P>0.05),且均未出现严重不良反应。结论采用皮秒翠绿宝石点阵激光联合氨甲环酸治疗脂溢性角化病的效果较好,且有助于改善性激素水平。
Objective To explore the therapeutic effect of picosecond alexandrite lattice laser combined with tranexamic acid in the treatment of seborrheic keratosis and its effect on sex hormones.Methods From March 2017 to January 2019,238 patients with seborrheic keratosis admitted to department of dermatology were randomly divided into control group and observation group,119 patients in each group.The control group was treated by ultra-pulse carbon dioxide laser.The observation group was treated by picosecond alexandrite lattice laser combined with tranexamic acid.Each group was treated by appropriate energy according to the location and properties of the lesion.All patients were followed up at 3 months after the treatment finished.Dermatology life quality index(DLQI),sex hormones level(E2,FSH,LH)and adverse reactions between 2 groups were recorded.Results The effective rate of the control group was 72.3%and the cure rate was 29.4%.The effective rate of the observation group was 78.2%and the cure rate was 58.0%.The cure rate of the observation group after one treatment was significantly better than that of the control group(P<0.001).There was no significant difference in the effective rate(P>0.05).The level of E2,FSH and LH of the observation group was lower than those before the treatment(P<0.05).The DLQI scores of both groups were lower than those before the treatment(P<0.05).There was no significant difference between two groups(P>0.05).No serious adverse reactions occurred.Conclusion Picosecond alexandrite lattice laser combined with tranexamic acid had a good therapeutic effect on seborrheic keratosis patients.This method could help to improve the level of sex hormones.
作者
杨蓉弟
李二龙
YANG Rong-di;LI Er-long(Department of Dermatology,West China Hospital of Sichuan University,Chengdu 610041,China)
出处
《中国美容整形外科杂志》
CAS
2020年第2期100-102,133,共4页
Chinese Journal of Aesthetic and Plastic Surgery
关键词
脂溢性角化
皮秒
氨甲环酸
性激素
痊愈率
Seborrheic keratosis
Picosecond
Tranexamic acid
Sex hormone
Cure rate
