摘要
目的:分析高迁移率族蛋白B1(HMGB1)、糖基化终末产物受体(RAGE)水平与子痫前期病情程度的相关性。方法:回顾性分析2020年2月至2021年2月该院收治的63例子痫前期患者的临床资料,根据子痫前期病情程度分为轻度组31例和重度组32例,另选取32名正常妊娠孕妇为对照组。检测三组HMGB1、RAGE蛋白表达水平,分析HMGB1、RAGE水平与子痫前期病情程度的相关性。结果:重度组、轻度组胎盘组织和血清中HMGB1、RAGE蛋白表达水平均高于对照组,且重度组高于轻度组,差异均有统计学意义(P<0.05);子痫前期患者HMGB1、RAGE水平与子痫前期病情程度呈正相关(r>0,P<0.05)。结论:HMGB1、RAGE水平与子痫前期病情程度呈正相关。
Objective:To analyze correlations among high mobility group protein B1(HMGB1)and glycation end product receptor(RAGE)levels and severity of preeclampsia.Methods:The clinical data of 63 patients with preeclampsia admitted to this hospital from February 2020 to February 2021 were retrospectively analyzed.According to the severity of preeclampsia,they were divided into mild group(31 cases)and severe group(32 cases);another 32 normal pregnant women were selected as control group.The expression levels of HMGB1 and RAGE proteins in the three groups were detected,Analyzing the correlation between HMGB1,RAGE levels and the severity of preeclampsia.Results:The expression levels of HMGB1 and RAGE proteins in placenta and serum of the mild group were higher than those of the control group,those of the severe group were higher than those of the mild group,and the differences were statistically significant(P<0.05).The levels of HMGB1 and RAGE in the patients with preeclampsia were positively correlated with the severity of preeclampsia(r>0,P<0.05).Conclusions:The levels of HMGB1 and RAGE are positively correlated with the severity of preeclampsia.
作者
陈洁
CHEN Jie(Department of Gynecology of Chengxin Hospital of Yuncheng County,Heze 274700 Shandong,China)
出处
《中国民康医学》
2023年第7期159-161,共3页
Medical Journal of Chinese People’s Health
作者简介
陈洁(1987.06-),女,汉族,山东菏泽人,本科,主治医师,研究方向为妇产科临床。
