摘要
重度子痫前期属于临床产科中所特有的一种危重症类疾病,主要表现为血压和尿蛋白增高,同时伴有血小板降低、肝功能异常等症状,是孕妇和围产儿死亡率升高的主要原因。尽管子痫前期的确切的发病机制尚未明确,但人们认为子痫前期的发生与氧化应激、炎症和动脉血管内皮损伤所致的不良胎盘诱发的"胎盘功能障碍"有关。铁死亡是近年来发现的一种新的程序性细胞死亡,其特征是脂质活性氧大量堆积,使细胞氧化还原反应失衡导致细胞死亡,研究显示铁死亡在妊娠期相关疾病中起着重要的作用。本文将对铁死亡发生机制及其在重度子痫前期发生发展中的作用进行综述。
Severe preeclampsia is a critical disease unique to clinical obstetrics.It is mainly manifested as increased blood pressure and urinary protein,accompanied by thrombocytopenia,abnormal liver function and other symptoms,and is the main cause of increased maternal and perinatal mortality.Although the exact pathogenesis of pre-eclampsia is not yet clear,it is thought that the occurrence of pre-eclampsia is related to oxidative stress,inflammation,and"placental dysfunction"induced by adverse placental conditions resulting from vascular endothelial damage.Ferroptosis is a new type of programmed cell death discovered in recent years,which is characterized by a large amount of accumulation of lipid reactive oxygen species,which leads to cell death due to imbalance of cell redox reaction.Studies have shown that ferroptosis plays an important role in pregnancy-related diseases.This article will review the mechanism of ferroptosis and its role in the development of severe preeclampsia.
作者
宋鹏书(综述)
何升(审校)
SONG Peng-shu;HE Sheng(Institute of Birth Defects,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning 530003,China)
出处
《中国优生与遗传杂志》
2020年第5期652-654,共3页
Chinese Journal of Birth Health & Heredity
基金
国家自然科学基金项目(81660034)
作者简介
通讯作者:何升
