摘要
乌梅丸是《伤寒论》治疗厥阴病的主方,主治“蛔厥”“久痢”。现代拓展其临床运用,治疗多系统疾病取得很好的临床疗效,近些年药理学研究阐明乌梅丸具有抗炎、调节免疫、调节肠道菌群、调节多调信号通路、降血糖、降血压、抑制肝纤维化、改善哮喘气道重塑、抗肿瘤等药理作用,体现了乌梅丸多靶点、多通路治疗多种疾病的特点。今后需要对乌梅丸发挥作用的药效学成分进行分析,构建活性成分、靶点、信号通路的药理学完整体系,充分挖掘乌梅丸的临床运用价值,做到古方新用。
Wumei Pill(乌梅丸)is the main prescription of Treatise on Febrile Diseases for Jueyin disease,mainly for“Huijue”and“Jiuli”.Modern expansion of clinical application has achieved good clinical efficacy in the treatment of multi-system diseases.In recent years,pharmacological studies have shown that Wumei Pill has anti-inflammatory,immune regulation,intestinal flora regulation,multiregulated signaling pathways,hypoglycemic,and hypotensive,inhibiting liver fibrosis,improving asthma airway remodeling,anti-tumor and other pharmacological effects,reflecting the characteristics of Wumei Pill multi-target and multi-channel treatment of various diseases.In the future,it is necessary to analyze the pharmacodynamic components of Wumei Pill,build a complete pharmacological system of active ingredients,targets,and signaling pathways,fully explore the clinical application value of Wumei Pill,and achieve new uses of ancient recipes.
作者
王秀芳
牛鑫
姚娓
WANG Xiufang;NIU Xin;YAO Wei(Second Affiliated Hospital of Dalian Medical University,Dalian 116023,Liaoning,China;Dalian Medical University,Dalian 116044,Liaoning,China)
出处
《辽宁中医药大学学报》
CAS
2023年第3期136-141,共6页
Journal of Liaoning University of Traditional Chinese Medicine
基金
第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]1号)
辽宁省优秀中医临床人才培养项目(辽卫办发〔2021〕29号)
大连医科大学附属第二医院院内培育项目(dy2yynpy202218)。
关键词
乌梅丸
临床应用
药理研究
综述
Wumei Pill(乌梅丸)
clinical application
pharmacological research
review
作者简介
王秀芳(1997-),女,甘肃陇南人,硕士在读,研究方向:中西医结合对老年病的临床治疗及实验研究;通讯作者:姚娓(1977-),女,辽宁大连人,教授、主任医师,硕士研究生导师,博士,研究方向:中西医结合对老年病的临床及实验研究。
