摘要
目的探讨非典型鳞状上皮化生患者的人乳头瘤病毒(HPV)感染情况。方法选取2019年5月至2021年2月于荆州市第三人民医院就诊的276例检出未明确诊断的非典型鳞状上皮细胞(ASCUS)患者为研究对象,患者居住地为荆州市,均经宫颈液基薄层细胞学检查。联合检测HPV分型(28个型)后结合临床最终诊断结果进行统计分析。结果276例ASCUS患者中,HPV感染者仅占28.26%(78/276)。HPV感染组与无HPV感染组的疾病类型比较,差异有统计学意义(P<0.05),HPV感染者存在癌变可能(或确诊癌变)的占比高于无HPV感染者。而有HPV感染者以单一感染为主,占总HPV阳性患者的71.79%(56/78),单一型别主要为52、58和18型。单一HPV感染组与多重HPV感染组的疾病类型比较,差异有统计学意义(P<0.05),多重HPV感染者存在癌变可能(或确诊癌变)的占比高于单一感染者。结论当前ASCUS患者多数为无HPV感染者,而有HPV感染者以单一型别感染为主,主要为HPV52、HPV58、HPV18型,且有HPV感染者、多重感染者的癌变可能更高。
Objective To investigate the human papillomavirus(HPV)infection in patients with atypical squamous metaplasia.Methods A total of 276 patients with undiagnosed atypical squamous cell(ASCUS)admitted to the Third People's Hospital of Jingzhou City from May 2019 to February 2021 were selected as the research objects.All patients lived in Jingzhou City and underwent cervical thin-prep cytology test.After the combined detection of HPV typing(28 types),statistical analysis was conducted based on the final clinical diagnosis results.Results Only 28.26%(78/276)of the 276 patients with ASCUS were infected with HPV.The difference of disease types between HPV infection group and no HPV infection group was statistically significant(P<0.05),and the proportion of HPV infected people with possible cancer(or confirmed cancer)was higher than that of HPV infected people without HPV.The majority of HPV infected patients were single infection,accounting for 71.79%(56/78)of the total HPV positive patients,and the single types were mainly 52,58 and 18.The difference of disease types between the single HPV infection group and the multiple HPV infection group was statistically significant(P<0.05),and the proportion of multiple HPV infection patients with possible(or confirmed)cancer was higher than that of the single HPV infection group.Conclusion Currently,most of the patients with ASCUS are HPV-free,while the majority of those with HPV are monotypic,mainly HPV52,HPV58 and HPV18,and the carcinogenesis of those with HPV and multiple infections may be higher.
作者
朱真
ZHU Zhen(Clinical Laboratory,the Third People's Hospital of Jingzhou,Hubei Province,Jingzhou 434001,China)
出处
《中国当代医药》
CAS
2023年第8期163-166,共4页
China Modern Medicine
