摘要
目的研究六安裕安区机会性筛查人群中高危型人乳头瘤病毒(HR-HPV)感染性特点,了解宫颈病变中HR-HPV情况,并探讨HR-HPV在不同宫颈病变中的感染特点。方法筛选2018年11月~2019年11月就诊于六安世立医院妇科门诊及体检中心接受宫颈癌机会性筛查的病例1839例作为研究对象。采用聚合酶链式反应(PCR)荧光定量的方法对13种HR-HPV进行检测,进一步对HR-HPV检测结果与宫颈液基薄层细胞学(TCT)检查结果进行比较分析,并分析HR-HPV感染亚型分布情况及与宫颈病变的关系。结果1839例患者中,HR-HPV阳性感染者检测出407例,HR-HPV总体感染率为22.13%;其中,52型HR-HPV感染最多,其次是16型和58型。HR-HPV感染随着患者年龄的增长而逐渐增高,其中>60岁组感染率最高,达36.92%。在TCT检查中,被诊断为腺上皮病变倾向于腺癌病例中HR-HPV感染率最高,达100.00%。被诊断为低度病变的病例中感染最多的HR-HPV型别为52型,而高度病变和鳞状细胞癌的病例中感染最多的HR-HPV型别为16型。结论在六安市裕安区机会性筛查人群中,52型HR-HPV感染最多;其次是16型,但是感染16型HPV的患者中宫颈病变更重。当检测出相应HR-HPV感染型别,应临床及时干预治疗,预防宫颈癌的发生。
Objective To study the infection characteristics of high-risk human papillomavirus(HR-HPV)in the opportunistic screening population of Yu′an District in Lu′an City,to understand the HR-HPV in cervical lesions,and to explore the infection characteristics of HR-HPV in different cervical lesions.Methods From November 2018 to November 2019,1839 cases who received opportunistic screening for cervical cancer in the Gynecological Outpatient and Physical Examination Center of Lu′an Shili Hospital were selected as the research subjects.The polymerase chain reaction(PCR)fluorescence quantitative was used to detect 13 kinds of HR-HPV,and the results of HR-HPV detection and cervical liquid-based thin layer cytology(TCT)were further compared and analyzed.The distribution of HR-HPV infection subtypes and its relationship with cervical lesions were also analyzed.Results Among the 1839 patients,407 cases of HR-HPV were positive.The overall HR-HPV infection rate was 22.13%.Among them,type 52 HR-HPV was the most infected,followed by type 16 and type 58.The infection rate of HR-HPV gradually increased with the increase of age,and the infection rate in the group aged over 60 years was as high as 36.92%.In the TCT examination,the HR-HPV infection rate reached 100.00%in the cases diagnosed as glandular epithelial lesions tending to adenocarcinoma.The most infected HR-HPV type in the cases diagnosed as low-grade disease was type 52,while the most infected HR-HPV type in the cases of high-grade disease and squamous cell carcinoma was type 16.Conclusion In the population of opportunistic screening of Yu′an District in Lu′an City,type 52 HR-HPV is the most infected,followed by type 16,but cervical disease is more severe among patients infected with type 16 HPV.When the corresponding HR-HPV infection type is detected,clinical intervention and treatment should be timely to prevent the occurrence of cervical cancer.
作者
金光玉
JIN Guang-yu(Department of Pathology,Lu′an Shili Hospital,Anhui Province,Lu′an237000,China)
出处
《中国当代医药》
CAS
2021年第14期188-192,共5页
China Modern Medicine
关键词
高危型人乳头瘤病毒
宫颈液基薄层细胞学检测
宫颈病变
High-risk human papillomavirus
Cervical liquid-based thin layer cytology
Cervical lesions
作者简介
金光玉(1975-),女,副主任医师,研究方向:病理诊断。
