摘要
溃疡性结肠炎(ulcerative colitis,UC)是病变累及结直肠黏膜的一种慢性特发性炎性疾病,其发病原因主要涉及遗传,肠道微生态和黏膜免疫系统失调等因素,越来越多的研究证实,细胞信号通路与炎症的发生密切相关。通过查阅文献,梳理了近年来中药复方治疗UC的相关通路,并阐述其可能的作用机制,为进一步开展临床及基础研究提供思路。通过梳理相关文献发现,中药复方治疗UC的机制主要涉及以下5条通路,酪氨酸激酶(Janus kinase-signal transducer,JAK)信号转导子与转录激活子(activator of tran-ions,STAT)信号通路、有丝分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPKs)信号通路、核因子κB(nuclear factor kappa-B,NF-κB)信号通路、Notch信号通路、磷脂酰肌醇激酶(phosphatidylinositide 3-kinases,PI3K)与蛋白激酶(protein Kinase,Akt)信号通路。中药复方通过调节多通路下的细胞间分子信息传递,发挥保护肠黏膜屏障、调控机体免疫反应、调节细胞因子等作用,对UC起到显著的治疗作用,同时体现了中药复方多靶点、多机制、多途径的优势。
Ulcerative colitis(UC)is a chronic idiopathic inflammatory disease involving the colorectal mucosa.Its causes include genetics,intestinal microecology,and mucosal immune system disorders and so on.More and more studies have confirmed that the cellular signaling pathway is closely related to the occurrence of intestinal inflammation.By reviewing the literature published in recent years,this paper sorted out the relevant pathways and mechanisms involved in the treatment of UC by traditional Chinese medicine(TCM)compounds to provide ideas for further clinical and basic researches.This literature review uncovered that the mechanism of TCM compounds exerted the therapeutic effects against UC mainly involved the following five pathways,Janus kinase-signal transducer(JAK)-activator of tranions(STAT)signaling pathway,P38-mitogen-activated protein kinase(MAPK)signaling pathway,nuclear factor kappa-B(NF-κB)signaling pathway,Notch signaling pathway and phosphatidylinositide 3-kinases(PI3K)-protein kinase(Akt)signaling pathway.TCM compounds can regulate the intercellular molecular transmission in multiple pathways to protect the intestinal mucosal barrier,adjust the immune response and regulatory cytokine and relieve UC,demonstrating the multi-target,multi-mechanism and multi-pathway advantages of TCM compounds.
作者
陈双兰
刘青松
张怡
谢子妍
CHEN Shuanglan;LIU Qingsong;ZHANG Yi;XIE Ziyan(Affliated Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,Sichuan,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第1期107-111,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81973821)。
关键词
溃疡性结肠炎
中药复方
信号通路
综述
ulcerative colitis
traditional Chinese medicine compound
signal pathway
review
作者简介
陈双兰(1997-),女,四川宜宾人,硕士在读,研究方向:中医药防治脾胃病;通讯作者:张怡(1967-),女,四川成都人,教授、主任医师,硕士研究生导师,硕士,研究方向:中医脾胃系疾病的防治。E-mail:zhangyi2288@163.com。
