摘要
细胞外囊泡(EV)是脂质双层包裹的微型囊泡,广泛存在于各种生物体液中,并可通过转运多种生物活性物质调节细胞的分子通路和生物学行为,特别是微小RNA(miRNA)。近年研究发现细胞外囊泡中的miRNA在动脉粥样硬化的发生和发展中发挥重要的调节作用。本文综述了动脉粥样硬化时细胞外囊泡miRNA转移的选择性及其在动脉粥样硬化发展过程中的调控作用和在诊断治疗中的潜在应用前景。
Extracellular vesicles are lipid bilayer-enclosed micro-vesicles generally existed in many biological fluids,and mediate molecular pathways and biological behavior of recipient cells by transferring various bioactive molecules to target cells,such as microRNA(miRNA).Recent studies have found that miRNA in extracellular vesicles plays an important role in the occurrence and development of atherosclerosis.This article reviews the selectivity of extracellular vesicular miRNA transfer in atherosclerosis,its regulatory role in the development of atherosclerosis,and its potential application in diagnosis and treatment.
作者
罗宇霖
袁渊
罗茂
LUO Yulin;YUAN Yuan;LUO Mao(Clinical Research Center,the Affiliated TCM Hospital of Southwest Medical University,Luzhou,Sichuan 646000,China;Drug Discovery Research Center,Southwest Medical University,Luzhou,Sichuan 646000,China)
出处
《中国动脉硬化杂志》
CAS
2023年第2期157-164,170,共9页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81800434)
四川省科技厅项目(2019YJ0487)
四川省留学人员科技活动项目择优资助项目[川人社办发(2020)291号]。
作者简介
罗宇霖,硕士研究生,研究方向为心血管药理学,E-mail:lyl19931225@163.com;通信作者:罗茂,博士,研究员,研究方向为心血管药理,E-mail:luomao20050908@163.com。
