摘要
微小RNA(miRNA)是一类在进化上高度保守的非编码小分子单链RNA(约18~24个碱基),在转录后水平负性调控基因表达。易损斑块是指动脉粥样硬化过程中易于形成血栓或可能迅速进展为罪犯病变的斑块。研究表明,miRNA几乎参与了动脉粥样硬化形成的所有步骤,包括内皮细胞及血管平滑肌细胞损伤和功能障碍、单核细胞浸润及血小板功能障碍,并发挥有益或有害作用。miRNA也将成为深入研究中医药双向调节易损斑块作用机制新的领域。
MicroRNA(miRNA) is a kind of evolutionarily highly conserved noncoding small molecule single stranded RNA(about 18-24 nucleotides), which negatively regulates gene expression at posttranscriptional level. Vulnerable plaques refer to plaques that are easy to form thrombus or may rapidly develop into criminal lesions in the process of atherosclerosis. Research shows that miRNA is involved in almost all steps of atherosclerosis, including endothelial cell and vascular smooth muscle cell injury and dysfunction, monocyte infiltration and platelet dysfunction, and plays a beneficial or harmful role. MiRNA will also become a new field to further study the mechanism of bidirectional regulation of vulnerable plaque by traditional Chinese medicine.
作者
瞿媛
顾宁
QU Yuan;GU Ning(Emergency Department,Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210001,China;Cardiovascular Department,Nanjing Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210001,China)
出处
《中国动脉硬化杂志》
CAS
2020年第6期548-552,共5页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金面上项目(81774229)
江苏省自然科学基金面上研究项目(BK20161115)
“十三五”南京市医学科技创新平台重大项目(ZDX16009)
江苏省中医药领军人才培养项目(苏中医科教[2018]4号)
南京市中医院科研基金项目(YJLC201901)。
关键词
微小RNA
动脉粥样硬化
易损斑块
内皮细胞
单核细胞
血管平滑肌细胞
血小板
中医
microRNA
atherosclerosis
vulnerable plaque
endothelial cell
monocyte
vascular smooth muscle cell
platelet
traditional Chinese medicine
作者简介
輯媛,博士研究生,副主任中医师,研究方向为中医及中西医结合防治心血管疾病,E-mail:quyuan0811@163.com;通信作者:顾宁,博士,主任中医师,博士研究生导师,研究方向为中医及中西医结合防治心血管疾病,E-mail:jsguning@163.com。
