摘要
目的探讨儿童系统性红斑狼疮(SLE)采用白芍总苷胶囊联合泼尼松片治疗的疗效。方法选取2019年1月至2022年7月濮阳市人民医院儿科收治的共计82例SLE患儿,按照随机数字表法分成治疗组(N=41)与对照组(N=41),对照组采用泼尼松片治疗,治疗组采用白芍总苷胶囊联合泼尼松片治疗。对两组临床疗效、免疫功能、肝肾功能及不良反应发生情况进行比较。结果治疗组治疗有效率(95.12%)较对照组(80.49%)更高,差异有统计学意义(P<0.05);治疗后两组补体3(C3)、补体4(C4)水平较治疗前提高,差异有统计学意义(P<0.05);免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平较治疗前降低,差异有统计学意义(P<0.05),与对照组比较,治疗组C3水平更高,差异有统计学意义(P<0.05),IgA、IgG、IgM水平更低,差异有统计学意义(P<0.05);治疗后两组谷草转氨酶(AST)、谷丙转氨酶(ALT)、血肌酐(Cr)及血尿素氮(BUN)水平降低,差异有统计学意义(P<0.05),治疗组水平较对照组更低,差异有统计学意义(P<0.05);治疗组不良反应发生率(4.88%)较对照组(21.95%)更低,差异有统计学意义(P<0.05)。结论白芍总苷胶囊联合泼尼松片用于治疗儿童SLE,能够提高临床疗效,增强机体免疫功能,促进患儿肝肾功能恢复,降低不良反应发生率。
Objective To investigate the effect of total glucosides of paeony(TGP)capsule combined with prednisone tablets on children with systemic lupus erythematosus(SLE).Methods From January 2019 to July 2022,a total of 82 children with SLE who were admitted to the department of pediatrics of Puyang People's Hospital were randomly divided into the treatment group(N=41)and the control group(N=41).The control group was treated with prednisone tablets,and the treatment group was treated with total glucosides of paeony capsules combined with prednisone tablets.The clinical efficacy,immune function,liver and kidney function and adverse reactions of the two groups were compared.Results The effective rate of treatment group(95.12%)was higher than that of control group(80.49%),the difference was statistically significant(P<0.05);After treatment,the levels of complement 3(C3)and complement 4(C4)in the two groups were significantly higher than those before treatment(P<0.05);The levels of immunoglobulin A(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)were significantly lower than those before treatment(P<0.05);After treatment,the levels of AST,ALT,Cr and BUN in the two groups decreased significantly(P<0.05),the level in the treatment group was lower than that in the control group(P<0.05);The incidence of adverse reactions in the treatment group(4.88%)was lower than that in the control group(21.95%),with a statistically significant difference(P<0.05).Conclusion TGP capsule combined with prednisone tablets can improve the clinical efficacy,enhance the immune function,promote the recovery of liver and kidney function,and reduce the incidence of adverse reactions in children with SLE.
作者
张俊霞
时利玲
柴焕然
张敬芳
ZHANG Junxia;SHI Liling;CHAI Huanran;ZHANG Jingfang(Department of Pediatrics,Puyang People's Hospital,Puyang Henan 457000,China)
出处
《临床研究》
2023年第1期107-110,共4页
Clinical Research
关键词
系统性红斑狼疮儿童
白芍总苷胶囊
泼尼松片
疗效
免疫功能
children with systemic lupus erythematosus
total glucosides of paeony capsule
prednisone tablets
efficacy
immunity
作者简介
张俊霞,女,主治医师,硕士研究生。研究方向:系统性红斑狼疮的治疗;通讯作者:张敬芳,主任医师,3490825628@qq.com。
