摘要
选取黄酮类化合物中4种典型的化合物黄芩苷、黄芩素、槲皮素和芦丁,就其改善胰岛素抵抗(insulin resistence,IR)的作用及机制进行综述,指出这4种黄酮类化合物主要通过降糖、降脂、抗炎、抗氧化、影响胰岛素信号通路、改善内质网应激等方式改善IR,治疗2型糖尿病,未来临床可以黄酮类化合物作为抗糖尿病药物进行开发应用。
The action of improving IR and the mechanism of four typical flavonoids including baicalin,baicalein,quercetin and rutin were summarized after they were chosen,it was pointed out that the four flavonoids could improve IR and treat type two diabetes mellitus(T2DM)mainly by lowering the glucose and lipid,antiinflammatory effects,oxidation resistance,affecting insulin signaling pathway,and improving endoplasmic reticulum stress,in the future,flavonoids could be developed and utilized as antidiabetic drug in clinic.
作者
郭胜男
张莉
吴深涛
刘弘毅
GUO Shengnan;ZHANG Li;WU Shentao;LIU Hongyi(Endocrinology Department,First Teaching Hospital of Tianjin University of TCM,Tianjin 300380,China;TCM Department,Hedong District Shengshi Zhongkang Hospital;Endocrinology Department,The First Affiliated Hospital of Yunnan University of Chinese Medicine)
出处
《西部中医药》
2022年第11期144-148,共5页
Western Journal of Traditional Chinese Medicine
基金
国家自然科学基金地区基金(81760856)
云南省应用基础研究计划青年项目(2017FD174)
云南省应用基础研究计划中医联合面上项目(2018FF001-053)。
作者简介
郭胜男(1989-),女,博士学位,主治医师。研究方向:糖尿病及其并发症的中西医结合防治;通讯作者:刘弘毅(1987-),男,博士学位,硕士研究生导师,副教授,副主任医师。研究方向:糖尿病及其并发症的中医药防治。
