摘要
中医药的特色与优势促进了其治疗与胰岛素抵抗相关的慢性代谢性疾病如肥胖、糖尿病等的发展,但其尚不明确的作用机制极大限制了中药现代化、国际化和产业化。随着2代/3代基因测序技术的飞速发展,肠道菌群已成为中药作用机制研究的热点和新途径。为此,探讨肠道菌群及其代谢产物与胰岛素抵抗的关系,从中药复方、药对、单味药和活性成分不同角度系统分析中药通过调控肠道菌群改善胰岛素抵抗的研究进展,以期为阐释中药的作用机制提供研究思路与参考。
The characteristics and advantages of traditional Chinese medicine(TCM)have promoted the development of TCM in the treatment of chronic metabolic diseases such as obesity and diabetes related to insulin resistance.However,the ambiguity of their corresponding mechanisms has greatly limited the modernization,internationalization and industrialization of Chinese materia medica(CMM).With the rapid development of second-/three-generation gene sequencing technologies,gut microbiota has become a hotspot and a new approach to study the mechanisms of CMM.Therefore,in this review,we explored the relationship between gut microbiota,metabolites of gut microbiota and insulin resistance,and then analyzed the research progress of CMM in regulating gut microbiota to improve insulin resistance by formulae,herb pair,single herb and active ingredients,so as to provide new thoughts for studying the mechanism of CMM.
作者
王文晓
乐世俊
刘娟
冯五文
陈艳琰
鄢丹
唐于平
WANG Wen-xiao;YUE Shi-jun;LIU Juan;FENG Wu-wen;CHEN Yan-yan;YAN Dan;TANG Yu-ping(Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility,Shaanxi University of Chinese Medicine,Xi’an 712046,China;School of Pharmacy,Chengdu University of Chinese Medicine,Chengdu 610075,China;Beijing Key Laboratory of Bio-Characteristic Profiling for Evaluation of Rational Drug Use,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China)
出处
《中草药》
CAS
CSCD
北大核心
2020年第1期216-228,共13页
Chinese Traditional and Herbal Drugs
基金
国家“重大新药创制”科技重大专项(2017ZX09301-040)
国家自然科学基金青年基金项目(81903786)
陕西省自然科学基金项目(2019JQ-054)
陕西省高校科协青年人才托举计划项目(20190306)
陕西中医药大学学科创新团队(2019-YL10).
关键词
中药
胰岛素抵抗
肠道菌群
代谢产物
作用机制
Chinese materia medica
insulin resistance
gut microbiota
metabolites
mechanism
作者简介
王文晓,助理实验师,主要从事中药炮制研究。E-mail:zwangwenxiao@163.com;通信作者:乐世俊,讲师,主要从事中药效应物质及作用机制研究。E-mail:shijun_yue@163.com
