摘要
类风湿关节炎主要影响肢体关节,亦可影响筋脉肌肉,导致肌肉减少,形成痹痿并存之状。基于前期临床经验以及实验基础,提出脾气热则耗损脾精,以脾脏虚损,肌肉失养为发病本质;内外湿邪,肌肉濡渍,贯穿痹证整个病程的始终。基于“脾气热”病机观,提出健脾清热祛湿治疗原则,并进一步探讨健脾清热祛湿法干预类风湿肌少症的效应机制,推测与改善线粒体功能,改善炎性免疫反应、调节肠道菌群、调控泛素蛋白酶系统以及改善肥胖状态有关,为临床治疗类风湿肌少症提供参考。
Rheumatoid arthritis mainly affects the limb joints, but also affect the muscles, resulting in muscle reduction and the formation of "Bi syndrome" and "Wei syndrome". Based on the previous clinical experience and experimental basis, this paper proposes that spleen Qi heat consumes spleen essence, which is characterized by spleen deficiency and muscle dystrophy. Internal and external dampness evil and muscle infiltration run through the whole course of Bi syndrome. Based on the pathogenesis of "spleen Qi heat",the therapeutic principle of invigorating spleen, clearing heat and removing dampness was put forward, and the mechanism of rheumatoid cachexia was further explored. It was speculated that it was related to improving mitochondrial function and inflammatory immune response, regulating intestinal flora and ubiquitin protease system and improving obesity status, so as to provide reference for clinical treatment of rheumatoid cachexia.
作者
任爽
刘妍彤
张杰
REN Shuang;LIU Yangtong;ZHANG Jie(The First Hospital of China Medical University,Shengyang 110001,Liaoning,China)
出处
《中华中医药学刊》
CAS
北大核心
2022年第10期40-43,共4页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金(81973661)
国家自然科学基金青年科学基金(82104828)
全国中医临床特色技术传承骨干人才培训项目(国中医药办人教函[2018]224号)。
关键词
脾气热
类风湿关节炎
健脾
肌少症
spleen Qi heat
rheumatoid arthritis
strengthening spleen
cachexia
作者简介
任爽(1983-),女,辽宁沈阳人,副教授、副主任中医师,博士,研究方向:风湿免疫疾病的中西医结合诊治;通讯作者:张杰(1971-),女,辽宁沈阳人,教授、主任医师,博士研究生导师,博士,研究方向:风湿免疫疾病的中西医结合诊治。E-mail:zhangjie945@126.com。
