摘要
冠心病是一种由多个基因及环境因素相互作用所致的常见复杂性疾病,近年来发现冠心病与DNA甲基化为代表的表观遗传修饰关系密切。表观遗传学研究的是环境而非遗传序列本身对基因表达的影响,这与中医整体观念、天人相应的理论不谋而合。中医遵循整体观念,重视环境等外部因素对人体的影响,通过治疗达到机体内在的平衡状态。近年来,中医科研工作者关于冠心病中医证候的DNA甲基化内涵,以及中药干预冠心病的甲基化机制方面的研究取得较大进展,笔者通过梳理相关文献并进行总结阐述,以期为未来研究提供参考。
Coronary heart disease(CHD)is a common complex disease caused by the interaction of multiple genes and environmental factors.In recent years,it has been found that CHD is closely related to epigenetic modification represented by DNA methylation.Epigenetics studies the influence of environment rather than genetic sequence itself on gene expression,which coincides with the overall concept of traditional Chinese medicine(TCM)and the theory of correspondence between nature and man.TCM follows the overall concept,pays attention to the influence of external factors such as environment on the human body,and achieves the internal balance of the body through TCM treatment.In recent years,TCM researchers have made great progress in the research on the DNA methylation connotation of TCM syndromes of CHD and the methylation mechanism of TCM intervention in CHD.The author combed the relevant literature and summarized it in order to provide reference for future research.
作者
周明学
ZHOU Mingxue(Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;Brain-Heart Tongzhi Laboratory,Beijing Institute of Chinese Medicine,Beijing 100010,China)
出处
《中国动脉硬化杂志》
CAS
2022年第12期1013-1019,共7页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(81673744、82274287)。
关键词
DNA甲基化
表观遗传
冠心病
动脉粥样硬化
中医药
DNA methylation
epigenetic
coronary heart disease
atherosclerosis
traditional Chinese medicine
作者简介
周明学,中国中医科学院博士,清华大学博士后,研究员,硕士研究生导师,北京市科技新星,北京市卫生局215人才,从事心血管病的中西医结合研究20年。既往主持课题18项,参研十一五重大专项等8项。迄今共发表学术论文100余篇。获发明专利授权6项,获中华中医药学会科技一等奖等科技奖4项。担任教育部、市科委等多个专项基金评审专家,在多个市级以上学会任常务委员、委员等职务,E-mail:mingxue78@163.com。
