摘要
动脉粥样硬化病因机制复杂,可导致全身大中型血管损伤,导致冠状动脉粥样硬化性心脏病、颈动脉粥样硬化、缺血性中风等疾病。内皮细胞损伤是动脉粥样硬化始动环节,进一步明确中医药防治动脉粥样硬化的作用机制具有重要意义。痰瘀是动脉粥样硬化形成的重要病理因素,痰瘀同治法是动脉粥样硬化的常用治法。目前已有包含临床研究、基础研究等在内的多项痰瘀同治法针对内皮功能及内皮细胞的研究被报道,痰瘀同治法可通过调控血管舒缩因子、血管内皮炎症、血管重塑、血管微环境等机制保护内皮功能。文章将痰瘀同治法中药防治动脉粥样硬化内皮损伤的机制及临床研究的研究进展进行综述。
The etiological mechanism of atherosclerosis is complex,which can lead to the damage of large and medium-sized blood vessels in the whole body,leading to coronary atherosclerotic heart disease,carotid atherosclerosis,ischemic stroke and other diseases.Endothelial cell injury is the initial link of atherosclerosis.It is of great significance to further clarify the mechanism of traditional Chinese medicine(TCM)prevention and treatment of atherosclerosis.Phlegm stasis is an important pathological factor in the formation of atherosclerosis,and the stagnation of phlegm and blood stasis is a common treatment for atherosclerosis.At present,a number of studies on endothelial function and endothelial cells have been reported including clinical studies and basic studies.The stagnation of phlegm and blood stasis can protect endothelial function by regulating vasomotor factors,vascular endothelial inflammation,vascular remodeling,vascular microenvironment and other mechanisms.In this paper,the mechanism and clinical research progress of the stagnation of phlegm and blood stasis with TCM for the prevention and treatment of atherosclerotic endothelial injury were reviewed.
作者
吴茜
吕乾瑜
侯信铮
叶雪姣
王师菡
WU Qian;LYU Qianyu;HOU Xinzheng;YE Xuejiao;WANG Shihan(Department of Cardiology,Guang’an men Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)
出处
《天津中医药》
2025年第7期923-930,共8页
Tianjin Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82374421)
中国中医科学院科技创新工程(CI2021A00921)
北京市自然科学基金项目(7232311)。
关键词
动脉粥样硬化
痰瘀同治
内皮损伤
内皮细胞
atherosclerosis
stagnation of phlegm and blood stasis
endothelial injury
endothelial cell
作者简介
吴茜(1993-),女,博士,医师,研究方向为中西医结合防治心血管病;通讯作者:王师菡,E-mail:wangshihan91@126.com。
