摘要
肿瘤微环境在肿瘤的发生、发展、转移等环节起到至关重要的作用。多种中药多糖通过调控肿瘤微环境而展现出抗肿瘤作用。从肿瘤微环境的各个组成部分如肿瘤相关成纤维细胞、肿瘤免疫细胞、血管内皮细胞、细胞外基质出发,阐述黄芪多糖、猪苓多糖、香菇多糖、车前子多糖、人参多糖、羊栖菜多糖和枸杞多糖对肿瘤微环境的调控作用,为抗肿瘤中药多糖药物的研发提供参考。
The tumor microenvironment plays an important role in the occurrence,development,and metastasis of tumors.A variety of traditional Chinese medicine polysaccharides have anti-tumor effects by regulating the tumor microenvironment.Starting from various components of the tumor microenvironment,such as tumor-associated fibroblasts,tumor immune cells,vascular endothelial cells,and extracellular matrix,this paper describes the regulatory effects of astragalus polysaccharides,polyporus polysaccharides,lentinan,Semen plantaginis polysaccharides,ginseng polysaccharides,Sargassum fusiforme polysaccharides,and Lycium barbarum polysaccharides on the tumor microenvironment,which can provide reference for the research and development of anti-tumor traditional Chinese medicine polysaccharide drugs.
作者
安香霖
鲁金月
董辉
孟鑫
AN Xiang-lin;LU Jin-yue;DONG Hui;MENG Xin(Heilongjiang University of Chinese Medicine,Harbin 150040,China)
出处
《现代药物与临床》
CAS
2022年第9期2142-2147,共6页
Drugs & Clinic
基金
国家自然科学基金资助项目(81703685)
中国博士后科学基金项目(2017M621319)
黑龙江省自然科学基金项目(LH2019H056)
黑龙江省中医药科研项目(ZHY18-021)。
关键词
中药多糖
肿瘤微环境
抗肿瘤
肿瘤相关成纤维细胞
黄芪多糖
枸杞多糖
traditional Chinese medicine polysaccharides
tumor microenvironment
anti-tumor
tumor-associated fibroblast
astragalus polysaccharides
Lycium barbarum polysaccharides
作者简介
安香霖(1997-),女,硕士研究生,从事中药药效物质与质量标准的研究。E-mail:axl20210303@126.com;通信作者:孟鑫(1982-),男,副教授,博士,从事中药药效物质与质量标准的研究。E-mail:mengxin52309@163.com。
