摘要
目的:观察预防性应用卡前列素氨丁三醇注射液止血对Ⅱ度胎盘早剥剖宫产患者的影响。方法:选取2018年1月至2021年6月该院收治的95例Ⅱ度胎盘早剥剖宫产患者进行前瞻性研究,按照随机数字表法分为观察组48例与对照组47例。对照组用宫缩素常规止血,观察组在对照组基础上,于胎儿娩出后采用卡前列素氨丁三醇注射液止血,比较两组疗效、出血量、产后出血发生率、凝血功能指标[活化部分凝血酶原时间(APTT)、血浆纤维蛋白原(FIB)]水平、子宫复旧良好率、凝血功能异常发生率和产褥感染发生率。结果:观察组治疗总有效率为95.83%,明显高于对照组的80.85%,差异有统计学意义(P<0.05);观察组产后15 min、30 min、2 h、24 h出血量均少于对照组,差异有统计学意义(P<0.05);观察组产后出血发生率为6.25%,明显低于对照组的21.27%,差异有统计学意义(P<0.05);产后24 h,观察组APTT短于对照组,FIB水平高于对照组,差异有统计学意义(P<0.05);观察组子宫复旧良好率为87.50%,明显高于对照组的68.09%,差异有统计学意义(P<0.05);住院期间,两组凝血功能异常、产褥感染发生率比较,差异无统计学意义(P>0.05)。结论:在Ⅱ度胎盘早剥剖宫产患者中预防性应用卡前列素氨丁三醇注射液止血可提高其疗效和子宫复旧良好率,减少其出血量,降低产后出血发生率,改善其凝血功能。
Objective:To observe effects of prophylactic application of Carprostol tromethamine injection for hemostasis on cesarean section patients with second-degree placental abruption.Methods:A prospective study was performed on 95 cesarean section patients with seconddegree placental abruption admitted to this hospital from January 2018 to June 2021,and they were divided into observation group(48 cases)and control group(47 cases)according to the random number table method.The control group was treated with Oxytocin routine hemostasis,while the observation group was treated with Carprostol tromethamine injection for hemostasis after the delivery of the fetus on the basis of that of the control group.The curative effect,the bleeding volume,the incidence of postpartum hemorrhage,the coagulation function index levels[activated partial prothrombin time(APTT),plasma fibrinogen(FIB)],the good rate of uterine involution,the incidence of abnormal coagulation function,and the incidence of puerperal infection were compared between the two groups.Results:The total effective rate of treatment in the observation group was 95.83%,which was significantly higher than the control group of 80.85%,and the difference was statistically significant(P<0.05).The bleeding volumes of the observation group 15 min,30 min,2 h,and 24 h after the delivery were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of postpartum hemorrhage in the observation group was 6.25%,which was significantly lower than the control group of 21.27%,and the difference was statistically significant(P<0.05).At postpartum 24 h,the APTT in the observation group was shorter than that in the control group,the level of FIB was higher than that in the control group,and the differences were statistically significant(P<0.05).The good rate of uterine involution in the observation group was 87.50%,which was significantly higher than the control group of 68.09%,and the difference was statistically significant(P<0.05).During the hospitalization,there were no significant differences in the incidences of abnormal blood coagulation function and puerperal infection between the two groups(P>0.05).Conclusions:Prophylactic application of c Carprostol tromethamine injection for hemostasis in the cesarean section patients with second-degree placental abruption can improve the curative effect and the good rate of uterine involution,reduce the bleeding volume and the incidence of postpartum hemorrhage,and improve the coagulation function.
作者
黄海锦
张媛
张源凤
周燕
HUANG Haijin;ZHANG Yuan;ZHANG Yuanfeng;ZHOU Yan(Department of Obstetrics of Yangjiang Maternal and Child Health Hospital,Yangjiang 529500 Guangdong,China)
出处
《中国民康医学》
2022年第18期27-30,共4页
Medical Journal of Chinese People’s Health
关键词
Ⅱ度胎盘早剥
产后
出血
卡前列素氨丁三醇
凝血
宫缩素
Degree Ⅱ placental abruption
Postpartum
Hemorrhage
Carprostol tromethamine
Coagulation
Oxytocin
作者简介
黄海锦(1988.09-),女,汉族,海南海口人,本科,主治医师,研究方向为妇产科疾病。
