摘要
目的 分析脑梗死患者选择阿司匹林与氯吡格雷联合治疗的临床效果及对神经功能的影响。方法 78例脑梗死患者,采用计算机随机法分为对照组和观察组,每组39例。两组均接受常规基础治疗,在此基础上,对照组加用阿司匹林治疗,观察组加用阿司匹林联合氯吡格雷治疗。比较两组神经功能缺损程度、临床疗效、不良反应发生情况、日常生活活动能力、生活质量。结果 治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分均较本组治疗前明显降低,且观察组NIHSS评分(15.05±2.23)分低于对照组的(18.45±3.15)分,差异具有统计学意义(P<0.05)。观察组治疗总有效率为94.87%,高于对照组的76.92%,差异具有统计学意义(P<0.05)。观察组不良反应发生率为5.13%,低于对照组的20.51%,差异具有统计学意义(P<0.05)。治疗后,两组日常生活活动能力量表(ADL)评分均较本组治疗前明显提升,且观察组ADL评分(78.05±5.23)分高于对照组的(70.63±5.27)分,差异具有统计学意义(P<0.05)。治疗后,观察组社会能力、情绪情况、疼痛程度、身体功能和活力评分分别为(86.32±3.55)、(88.42±3.16)、(90.03±2.35)、(87.26±3.14)、(86.43±3.11)分,均高于对照组的(83.81±3.27)、(85.87±3.09)、(88.39±2.41)、(85.12±2.88)、(84.69±2.96)分,差异具有统计学意义(P<0.05)。结论 脑梗死患者在常规治疗的基础上联合使用阿司匹林与氯吡格雷,可提升治疗效果,降低神经功能缺损程度,改善其日常生活活动能力及生活质量,且用药方案安全性理想,具有较高的临床应用及推广价值。
Objective To analyze the clinical effect of aspirin and clopidogrel in the treatment of cerebral infarction and its influence on neurological function. Methods A total of 78 patients with cerebral infarction were conventional divided into control group and observation group, with 39 cases in each group. Both groups received routine basic treatment. On this basis, the control group was additionally treated with aspirin, and the observation group was additionally treated with aspirin combined with clopidogrel. The degree of neurological deficit, clinical efficacy, occurrence of adverse reactions, activities of daily living, and quality of life were compared between the two groups. Results After treatment, the National Institutes of Health stroke scale(NIHSS) scores in the two groups were significantly lower than those before treatment in this group, and the NIHSS score(15.05±2.23) points in the observation group was lower than(18.45±3.15) points in the control group. All the differences were statistically significant(P<0.05). The total effective rate of the observation group was 94.87%, which was higher than 76.92% of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 5.13%, which was lower than 20.51% in the control group, and the difference was statistically significant(P<0.05). After treatment, the activities of daily living(ADL) scores in the two groups were significantly improved compared with those before treatment in this group, and the ADL score(78.05±5.23) points in the observation group was higher than(70.63±5.27) points in the control group. All the differences were statistically significant(P<0.05). After treatment, the scores of social ability, emotional state, pain level, physical function and vitality of the observation group were(86.32±3.55),(88.42±3.16),(90.03±2.35),(87.26±3.14) and(86.43±3.11) points, which were higher than(83.81±3.27),(85.87±3.09),(88.39±2.41),(85.12±2.88) and(84.69±2.96) points of the control group, and the differences were statistically significant(P<0.05). Conclusion The combined use of aspirin and clopidogrel in patients with cerebral infarction on the basis of conventional treatment can enhance the therapeutic effect, reduce the degree of neurological deficits,improve their activities of daily living and quality of life, and the safety of the drug regimen is ideal, which has high value of clinical application and promotion.
作者
范驰
王瑞萍
FAN Chi;WANG Rui-ping(Department of Neurology,Jinqiu Hospital,Shenyang 110000,China)
出处
《中国实用医药》
2022年第18期6-10,共5页
China Practical Medicine
关键词
阿司匹林
氯吡格雷
脑梗死
神经功能
生活质量
日常生活活动能力
Aspirin
Clopidogrel
Cerebral infarction
Neurological function
Quality of life
Activities of daily living
作者简介
通讯作者:王瑞萍。
