摘要
目的探讨阿司匹林联合氯吡格雷在急性脑梗死(ACI)患者中的应用效果.方法选取2019年11月—2022年3月本院收治的92例ACI患者,以随机数字表法分为观察组46例和对照组46例.对照组单独给予阿司匹林治疗,观察组在对照组基础上加服氯吡格雷片,持续给药治疗14 d.比较两组临床疗效、神经功能、认知功能及血小板聚集功能,并观察不良反应发生情况.结果观察组治疗总有效率为95.65%,高于对照组的80.43%,差异有统计学意义(P<0.05);治疗后,观察组美国国立卫生研究院卒中量表评分(7.85±0.54)分低于对照组,简易精神状态评定量表中语言能力评分(4.84±0.53)分、定向力评分(4.47±0.23)分、注意力和计算力评分(3.87±0.64)分、短时记忆力评分(2.42±0.38)分、回忆能力评分(1.98±0.35)分均高于对照组,花生四烯酸诱导下血小板最大聚集率(21.26±2.03)%及二磷酸腺苷诱导下血小板最大聚集率(31.58±5.33)%均低于对照组,组间差异有统计学意义(P<0.05);两组不良反应发生率相近,差异无统计学意义(P>0.05).结论阿司匹林与氯吡格雷联合应用于ACI患者效果确切,有助于改善神经功能、认知功能及血小板聚集功能,且安全性高,值得推广.
Objective To investigate the application effect of aspirin combined with clopidogrel in patients with acute cerebral infarction(ACI).Methods 92 patients with ACI admitted to the hospital from November 2019 to March 2022 were selected and divided into an observation group of 46 cases and a control group of 46 cases by random number table method.The control group was treated with aspirin alone,and the observation group was treated with clopidogrel tablets on the basis of the control group,with both interventions for 14 days.The clinical efficacy,neurological function,cognitive function and platelet aggregation function of the two groups were compared,and the occurrence of adverse reactions were observed.Results The total effective rate of treatment of the observation group was 95.65%,which was higher than 80.43%of the control group,with statistically significant differences between the groups(P<0.05);after treatment,the National Institutes of Health stroke scale score(7.85±0.54)points of the observation group was lower than that of the control group,the scores of language ability(4.84±0.53)points,orientation ability(4.47±0.23)points,attention and calculation ability(3.87±0.64)points,short-term memory ability(2.42±0.38)points,recall ability(1.98±0.35)points in mini mental state examination were higher than those of the control group,and the maximum platelet aggregation rate induced by arachidonic acid(21.26±2.03)%and the maximum platelet aggregation rate induced by adenosine diphosphate(31.58±5.33)%were lower than those of the control group,with statistically significant differences between the groups(P<0.05);the incidence of adverse reactions were similar between the two groups,with no statistically significant difference(P>0.05).Conclusion The combination of aspirin and clopidogrel in patients with ACI is very effective,which is helpful to improve the neurological function,cognitive function and platelet aggregation function.It has high safety and is worth promoting.
作者
王彦斐
WANG Yanfei(Department of Cerebrovascular Diseases,Lanling County People's Hospital,Linyi Shandong,276000,China)
出处
《反射疗法与康复医学》
2022年第19期153-156,共4页
Reflexology And Rehabilitation Medicine
关键词
急性脑梗死
阿司匹林
氯吡格雷
神经功能
认知功能
血小板聚集功能
Acute cerebral infarction
Aspirin
Clopidogrel
Neurological function
Cognitive function
Platelet aggregation function
作者简介
王彦斐(1987-),女,山东临沂人,本科,主治医师,研究方向:脑血管病科临床.
