摘要
目的探讨免疫球蛋白(Ig)G在系统性红斑狼疮(SLE)患者血清中的表达及其与患者发生肾功能损伤的相关性。方法选取2020年1月至2021年10月于金牛区第二人民医院就诊的SLE患者118例为研究对象,根据患者是否发生肾功能损伤,将其分为肾功能损伤组(41例)和非肾功能损伤组(77例),另选取体检健康者50例作为对照组。分别采集3组血液、尿液标本,比较3组血清IgG水平及肾功能相关指标;采用Pearson相关分析IgG与肾功能指标的相关性;采用受试者工作特征(ROC)曲线分析血清IgG诊断SLE患者发生肾功能损伤的临床价值。结果与对照组比较,肾功能损伤组和非肾功能损伤组血清IgG、IgA、IgM水平明显升高(P<0.05);与非肾功能损伤组比较,肾功能损伤组血清IgG、IgA、IgM水平明显升高(P<0.05);肾功能损伤组血肌酐、降钙素原、胱抑素C、尿素氮、尿酸水平明显高于非肾功能损伤组(P<0.05);Pearson相关结果显示,血清IgG水平与血肌酐、降钙素原、胱抑素C、尿素氮、尿酸均呈正相关(P<0.05);IgG诊断SLE患者发生肾功能损伤的曲线下面积为0.821(95%CI 0.762~1.549),约登指数为0.629,诊断灵敏度为89.73%,特异度为85.26%(P<0.05)。结论IgG在SLE患者血清中水平较高,其与SLE患者发生肾功能损伤密切相关。
Objective To investigate the expression of immunoglobulin(Ig)G in serum of patients with systemic lupus erythematosus(SLE)and its correlation with renal function damage.Methods A total of 118 SLE patients who were treated in Jinniu District Second People′s Hospital from January 2020 to October 2021 were selected as the research subjects.According to whether the patients had renal function damage,they were divided into renal function damage group(41 cases)and non-renal function damage group(77 cases),and 50 healthy persons examined in the hospital in the same period were selected as the control group.Blood and urine samples were collected from 3 groups,and serum IgG levels and renal function-related indexes were compared among the 3 groups;Pearson correlation was used to analyze the correlation between IgG and renal function indexes;receiver operating characteristic(ROC)curve was used to analyze the clinical value of serum IgG in the diagnosis of renal function damage in SLE patients.Results Compared with the control group,the levels of serum IgG,IgA and IgM in the renal function damage group and the non-renal function damage group were significantly increased(P<0.05);compared with the non-renal function damage group,the serum IgG,IgA and IgM levels in the renal function damage group were significantly increased(P<0.05).The levels of serum creatinine,procalcitonin,cystatin C,blood urea nitrogen and uric acid in the renal function damage group were significantly higher than those in the non-renal function damage group(P<0.05).Pearson correlation results showed that serum IgG was positively correlated with serum creatinine,procalcitonin,cystatin C,blood urea nitrogen and uric acid(P<0.05).The area under the curve of IgG for the diagnosis of renal function damage in SLE patients was 0.821(95%CI 0.762-1.549),the Youden index was 0.629,the diagnostic sensitivity was 89.73%,and the specificity was 85.26%(P<0.05).Conclusion IgG is highly expressed in the serum of SLE patients,which is closely related to the renal function damage in SLE patients.
作者
张燕
王刚
ZHANG Yan;WANG Gang(Department of Clinical Laboratory,Community Health Service Center,Renmin North Road,Jinniu District/the Second People′s Hospital of Jinniu District,Chengdu,Sichuan 610031,China;Clinical Laboratory Center of Sichuan Academy of Medical Sciences·Sichuan Provincial People′s Hospital,Chengdu,Sichuan 610072,China)
出处
《检验医学与临床》
CAS
2022年第17期2373-2375,共3页
Laboratory Medicine and Clinic
关键词
免疫球蛋白G
系统性红斑狼疮
肾功能损伤
相关性
immunoglobulin G
systemic lupus erythematosus
renal function damage
correlation
作者简介
张燕,女,主管技师,主要从事临床检验相关研究。
