摘要
目的:探讨计算机辅助认知功能训练(CACR)对脑卒中后认知功能障碍患者血清神经功能相关指标及生活能力的影响。方法:将80例脑卒中后认知功能障碍患者随机划分入对照组和观察组各40例,所有患者均接受常规治疗,在此基础上对照组实施作业疗法,观察组在对照组基础上开展CACR。于干预前、干预3个月后对2组采用简易精神状态评价量表(MMSE)评定认知功能,采用改良Barthel指数(MBI)评定生活能力,并检测2组血清视锥蛋白样蛋白-1(VILIP-1)、胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)水平。结果:干预后,2组MMSE、MBI评分和干预前相比均明显增高(P<0.05),且观察组均明显高于照组(P<0.05);干预后2组血清视锥蛋白样蛋白-1(VILIP-1)、胶质纤维酸性蛋白(GFAP)、神经元特异性烯醇化酶(NSE)水平和干预前相比均明显降低(P<0.05),且观察组均明显低于对照组(P<0.05)。结论:对脑卒中后认知障碍患者实施CACR结合作业疗法干预,可有效下调血清VILIP-1、GFAP、NSE表达,明显改善患者认知功能,显著提高生活能力。
Objective:To explore the effect of computer-assisted cognitive training(CACR)on serum neurological function related indexes and living ability in patients with cognitive impairment after stroke.Methods:All 80 patients with cognitive dysfunction after stroke admitted to our hospital were randomly divided into the control group(n=40)and the experimental group(n=40).All patients received routine therapy.Besides,the control group was given occupational therapy,and the experimental group was subjected to CACR.Before and 3 months after the intervention,the Mini-Mental State Evaluation(MMSE)was used to evaluate the cognitive function,and the modified Barthel Index(MBI)to assess the living ability.The levels of serum Visinin-like protein-1(VILIP-1),glial fibrillary acidic protein(GFAP)and neuron-specific enolase(NSE)were detected.Results:After the intervention,the MMSE and MBI scores in the two groups were significantly higher than those before the intervention(P<0.05),and those in the experimental group were significantly higher than in the control group(P<0.05);the levels of serum VILIP-1,GFAP,and NSE in the two groups were significantly lower than those before the intervention(P<0.05),and those in the experimental group were significantly lower than in the control group(P<0.05).Conclusion:The intervention of CACR combined with occupational therapy for patients with cognitive dysfunction after CS can effectively down-regulate the expression of serum VILIP-1,GFAP,and NSE,significantly improve the cognitive function of patients,and significantly improve their living ability.
作者
孟德敏
廖其华
廖家权
Meng Demin;Liao Qihua;Liao Jiaquan(Rehabilitation Medical Center of Enshi Tujia and Miao Autonomous Prefecture Central Hospital,Hubei Enshi 445000,China)
出处
《中国康复》
2022年第7期396-399,共4页
Chinese Journal of Rehabilitation
关键词
计算机辅助认知功能训练
作业疗法
脑卒中
认知功能障碍
生活能力
computer-assisted cognitive rehabilitation training
occupational therapy
stroke
cognitive dysfunction
living ability
作者简介
孟德敏(1991-),女,主治医师,主要从事神经康复方面的研究;通讯作者:廖家权,jfge98@163.com。
